Odds of achieving blood pressure control in the post-treatment period as a function of treatment regimen and risk factors (95% CI in parentheses)
| Variable | Kidney disease | Diabetes mellitus | Cardiovascular* | Low-risk patients | All patients |
| Age cohort | |||||
| Age ≤55 | |||||
| Age >55 | 0.897 (0.727 to1.107) | 0.854 (0.744 to 0.980) | 0.770 (0.730 to 0.812) | 0.785 (0.723 to 0.853) | 0.789 (0.757 to 0.822) |
| Sex | |||||
| Female | |||||
| Male | 1.016 (0.867 to 1.191) | 0.942 (0.823 to 1.077) | 0.797 (0.757 to 0.839) | 0.918 (0.846 to 0.996) | 0.851 (0.818 to 0.886) |
| Registration with practice | |||||
| Existing patient | |||||
| New patient | 1.103 (0.675 to 1.800) | 1.260 (0.898 to 1.769) | 1.053 (0.908 to 1.221) | 0.922 (0.743 to 1.143) | 1.032 (0.923 to 1.154) |
| History of hypertension | |||||
| No prior hypertension | |||||
| Prior episode of hypertension | 0.790 (0.673 to 0.928) | 0.715 (0.617 to 0.829) | 0.878 (0.828 to 0.931) | 0.847 (0.772 to 0.928) | 0.843 (0.806 to 0.882) |
| Comorbid conditions | |||||
| Diabetes | 1.061 (0.845 to 1.331) | 1.161 (1.085 to 1.242) | |||
| Kidney disease | 1.180 (1.088 to 1.280) | ||||
| Coronary heart disease | 1.133 (0.685 to 1.875) | 0.731 (0.317 to 1.686) | 1.134 (0.841 to 1.530) | 1.605 (0.859 to 3.001) | 1.138 (0.909 to 1.425) |
| Cerebrovascular disease | 1.034 (0.776 to 1.378) | 1.318 (0.936 to 1.858) | 1.254 (1.090 to 1.443) | 1.810 (1.314 to 2.493) | 1.278 (1.153 to 1.416) |
| Peripheral vascular disease | 0.797 (0.585 to 1.085) | 1.097 (0.905 to 1.330) | 1.168 (0.987 to 1.382) | 0.715 (0.417 to 1.226) | 1.056 (0.944 to 1.182) |
| Myocardial infarction | 1.103 (0.804 to 1.513) | 1.785 (1.210 to 2.633) | 1.161 (0.976 to 1.382) | 1.785 (1.349 to 2.363) | 1.315 (1.166 to 1.482) |
| Hyperlipidaemia | 0.976 (0.818 to 1.165) | 1.081 (0.932 to 1.255) | 1.086 (1.012 to 1.166) | 1.106 (0.991 to 1.233) | 1.078 (1.023 to 1.136) |
| Lifestyle factors | |||||
| Not current smoker | |||||
| Current smoker | 1.180 (0.973 to 1.431) | 0.936 (0.805 to 1.088) | 0.871 (0.821 to 0.924) | 0.998 (0.908 to 1.098) | 0.923 (0.882 to 0.967) |
| Not obese/overweight | |||||
| Overweight | 0.976 (0.813 to 1.171) | 1.199 (0.981 to 1.465) | 1.112 (1.046 to 1.183) | 1.074 (0.974 to 1.184) | 1.098 (1.046 to 1.152) |
| Obese | 0.974 (0.796 to 1.191) | 0.971 (0.802 to 1.177) | 0.874 (0.820 to 0.930) | 0.857 (0.774 to 0.948) | 0.881 (0.838 to 0.925) |
| Pretreatment hypertension grade | |||||
| Lower than grade 1 | |||||
| Grade 1 | 0.740 (0.547 to 1.001) | 0.556 (0.426 to 0.727) | 0.516 (0.328 to 0.812) | 0.589 (0.519 to 0.669) | 0.583 (0.527 to 0.644) |
| Grade 2 | 0.416 (0.309 to 0.559) | 0.343 (0.263 to 0.448) | 0.321 (0.206 to 0.501) | 0.374 (0.339 to 0.413) | |
| Grade 3 | 0.299 (0.216 to 0.414) | 0.184 (0.137 to 0.248) | 0.201 (0.129 to 0.314) | 0.234 (0.211 to 0.259) | |
| No pretreatment BP reading | 0.448 (0.263 to 0.765) | 0.330 (0.204 to 0.532) | 0.333 (0.283 to 0.391) | 0.340 (0.295 to 0.392) | |
| Initial therapy | |||||
| Monotherapy | |||||
| Combination therapy | 1.378 (0.981 to 1.937) | 1.138 (0.788 to 1.644) | 1.228 (1.061 to 1.421) | 1.118 (0.928 to 1.348) | 1.213 (1.093 to 1.346) |
| Number of observations | 2732 | 3892 | 27 438 | 9949 | 44 011 |
| Hosmer-Lemeshow goodness-of-fit | Fail | Pass | Pass | Pass | Pass |
| C-statistic | 0.62 | 0.64 | 0.59 | 0.59 | 0.62 |
*The cardiovascular risk group includes patients with grades 2 or 3 hypertension (with or without comorbid cardiovascular disease) prior to treatment initiation and those with ‘high normal’ or grade 1 hypertension plus one or more cardiovascular conditions (ie, coronary heart disease, cerebrovascular disease, peripheral vascular disease, myocardial infarction or hyperlipidaemia).
Bold text indicates statistical significance at the α=0.05 level on a two-tailed test estimated with stepdown Bonferroni correction of p values.