Mean and SD of baseline and change scores estimated using current and multilevel model approaches to responsiveness in a patient undergoing total hip replacement in the APEX cohort study
| Current approaches to responsiveness | MLM approaches to responsiveness | |||||||||
| Baseline | Change | Absolute threshold | P (resp.) | Baseline | Change | Absolute threshold | P (resp) | |||
| n | β0 σu0 | β1 σu1 | β0 σu0 | β1 σu1 | ||||||
| Return to normal | Total pain | 210 | 43.71 (22.1) | 45.76 (24.0) | 87.9 | 70.5 (63.8, 76.6) | 43.71 (20.1) | 46.14 (19.7) | 83.8 | 78.1 (71.9, 83.5) |
| MID | 210 | 11.0 | 91.9 (87.4, 95.2) | 10.0 | 97.6 (94.5, 99.2) | |||||
| MCID (satisfied) | 185 | 44.37 (22.0) | 48.43 (22.6) | 32.6 | 71.9 (65.3, 77.9) | 44.37 (20.3) | 48.54 (19.2) | 35.8 | 67.1 (74.5, 85.6) | |
| MCID (unsatisfied) | 25 | 38.77 (22.4) | 26.05 (25.4) | 38.77 (17.0) | 28.43 (16.3) | |||||
| Return to normal | Chronic pain | 210 | 49.19 (27.2) | 44.23 (27.3) | 103.5 | 0 (0, 1.7) | 49.19 (25.6) | 44.35 (24.0) | 100.3 | 0 (0, 1.7) |
| MID | 210 | 13.6 | 84.3 (78.6, 88.9) | 12.8 | 88.6 (83.5, 92.5) | |||||
| MCID (satisfied) | 185 | 50.08 (27.4) | 46.37 (26.7) | 30.0 | 72.4 (65.8, 78.3) | 50.08 (26.3) | 46.21 (24.5) | 31.0 | 73.3 (44.2, 58.9) | |
| MCID (unsatisfied) | 25 | 42.60 (24.8) | 28.40 (26.9) | 42.60 (18.3) | 30.60 (12.6) | |||||
| OO | 210 | 49.19 (27.2) | 44.23 (27.3) | 20(10) | 92.4 (87.9, 95.6) | 49.19 (25.3) | 44.35 (23.4) | 20(10) | 99.5 (54.8, 69) | |
| Return to normal | Intermittent pain | 210 | 39.13 (21.7) | 47.06 (26.5) | 82.5 | 70 (63.3, 76.1) | 39.13 (18.7) | 47.66 (20.5) | 76.5 | 80.5 (90.5, 97.4) |
| MID | 210 | 10.8 | 90 (85.1, 93.7) | 9.3 | 97.1 (30, 44.1) | |||||
| MCID (satisfied) | 185 | 39.60 (21.7) | 50.17 (24.9) | 37.5 | 71.4 (64.8, 77.4) | 39.60 (19.2) | 50.50 (19.1) | 40.5 | 67.1 (84.8, 93.9) | |
| MCID (unsatisfied) | 25 | 35.58 (21.4) | 24.08 (26.6) | 35.58 (13.9) | 26.69 (17.1) | |||||
| OO | 210 | 39.13 (21.7) | 47.06 (26.5) | 20(10) | 92.4 (87.9, 95.6) | 39.13 (18.5) | 47.66 (19.1) | 20(10) | 99.5 (60.3, 73.5) | |
Betas represent the population average characteristic and sigma the estimated SD. Baseline is assumed to be the day of surgery, and change is from 0 to 3 months.
MCID, minimal clinically Important difference; MID , minimally important difference; MLM, multilevel model; OO, OMERACT OARSI responder criteria; P (resp.), proportion of responders.