Adjusted HRs for main causes of deaths in women with Itai-itai disease and screened women with renal tubular dysfunction compared with controls matched for sex, age and occupation
| Groups | Controls | Screened cases | Patients with Itai-itai disease | |||||
| D | HR | D | HR | (95% CI) | D | HR | (95% CI) | |
| Malignant neoplasms | 25 | 1.00 | 17 | 1.76 | (0.94 to 3.28) | 11 | 1.42 | (0.69 to 2.91) |
| Stomach cancer | 8 | 1.00 | 4 | 1.49 | (0.44 to 5.01) | 2 | 0.81 | (0.17 to 3.87) |
| Colorectal cancer | 1 | 1.00 | 4 | 10.1 | (1.11 to 91.34) | 2 | 7.57 | (0.68 to 84.87) |
| Cardiovascular diseases | 43 | 1.00 | 14 | 1.07 | (0.58 to 1.98) | 19 | 1.87 | (1.08 to 3.24) |
| Ischaemic heart diseases | 9 | 1.00 | 7 | 2.30 | (0.84 to 6.28) | 6 | 3.00 | (1.04 to 8.70) |
| Cerebrovascular diseases | 45 | 1.00 | 16 | 0.99 | (0.56 to 1.76) | 13 | 1.07 | (0.57 to 2.00) |
| Cerebral infarction | 25 | 1.00 | 10 | 1.07 | (0.51 to 2.25) | 6 | 0.96 | (0.39 to 2.35) |
| Respiratory diseases | 33 | 1.00 | 11 | 1.13 | (0.56 to 2.25) | 30 | 3.96 | (2.39 to 6.58) |
| Pneumonia and influenza | 27 | 1.00 | 7 | 0.82 | (0.36 to 1.90) | 29 | 4.54 | (2.65 to 7.76) |
| Digestive diseases | 7 | 1.00 | 9 | 4.16 | (1.52 to 11.41) | 15 | 7.77 | (3.12 to 19.36) |
| Gastrointestinal tract diseases | 3 | 1.00 | 5 | 5.09 | (1.20 to 21.60) | 13 | 13.8 | (3.87 to 49.10) |
| Kidney and urinary tract diseases | 5 | 1.00 | 17 | 10.8 | (3.93 to 29.91) | 18 | 17.2 | (6.31 to 47.02) |
| Renal diseases | 4 | 1.00 | 15 | 12.0 | (3.92 to 36.78) | 16 | 19.5 | (6.43 to 59.09) |
| Cadmium poisoning | 0 | – | 0 | – | – | 18 | ||
Covariates, age at baseline, smoking status at present (yes: 1, no: 0) and hypertension history (yes: 1, no: 0).
D, number of deaths.