Adjusted HRs for main causes of deaths during the first 10 years in women with Itai-itai disease and screened women with renal tubular dysfunction compared with controls matched for sex, age and occupation
| Groups | Controls | Screened cases | Patients with Itai-itai disease | |||||
| D | HR | D | HR | (95% CI) | D | HR | (95% CI) | |
| Malignant neoplasms | 11 | 1.00 | 8 | 1.88 | (0.75 to 4.70) | 6 | 1.25 | (0.46 to 3.40) |
| Cardiovascular diseases | 25 | 1.00 | 5 | 0.68 | (0.26 to 1.80) | 13 | 1.74 | (0.88 to 3.44) |
| Cerebrovascular diseases | 23 | 1.00 | 11 | 1.35 | (0.65 to 2.80) | 7 | 0.88 | (0.38 to 2.07) |
| Respiratory diseases | 15 | 1.00 | 4 | 0.95 | (0.31 to 2.88) | 23 | 4.47 | (2.32 to 8.62) |
| Pneumonia and influenza | 14 | 1.00 | 3 | 0.74 | (0.21 to 2.61) | 23 | 4.77 | (2.44 to 9.33) |
| Digestive diseases | 3 | 1.00 | 6 | 4.16 | (1.52 to 11.41) | 13 | 13.1 | (3.70 to 46.45) |
| Gastrointestinal tract diseases | 1 | 1.00 | 3 | 8.97 | (0.92 to 87.14) | 13 | 37.1 | (4.81 to 286.0) |
| Kidney and urinary tract diseases | 1 | 1.00 | 6 | 18.9 | (2.24 to 160.0) | 7 | 23.2 | (2.83 to 190.1) |
| Renal diseases | 1 | 1.00 | 5 | 16.3 | (1.86 to 142.8) | 6 | 20.2 | (2.41 to 169.6) |
| Cadmium poisoning | 0 | – | 0 | – | – | 15 | ||
Covariates, age at baseline, smoking status at present (yes: 1, no: 0) and hypertension history (yes: 1, no: 0).
D, number of deaths.