Table 3

Comparison of clinical characteristics (on-admission) of fatal and non-fatal dengue cases

VariablesTotal cohort
(n=667)
Non-fatal cases
(n=659)
Fatal cases
(n=8)
p Value*
Age (years), mean±SD30.7±16.130.5±159748.8±25.60.083
 Age>40 years, n (%)167 (25%)161 (24.4%)6 (75%)0.004
 Age>60 years, n (%)35 (5.2%)33 (5.0%)2 (25%)0.061
Male gender, n (%)378 (56.7%)374 (56.8%)4 (50%)0.732
Secondary infection, n (%)73 (10.9%)70 (10.6%)3 (37.5%)0.047
Dengue severity, n (%)
 DF, n (%)588 (88%)582 (88.3%)6 (75%)0.243
 DHF†, n (%)79 (10.5%)77 (11.7%)2 (25%)0.243
Comorbidities, n (%)
DM, n (%)36 (5.4%)33 (5.0%)3 (37.5%)0.007
HTN, n (%)35 (5.2%)33 (5.0%)2 (25%)0.061
CKD, n (%)33 (4.9%)31 (4.7%)2 (25%)0.055
IHD, n (%)25 (3.7%)23 (3.5%)2 (25%)0.033
Comorbidities≥2, n (%)36 (5.4%)33 (5.0%)4 (50%)0.007
AKI, n (%)95 (14.2%)87 (13.2%)8 (100%)<0.001
Scr≥2 mg/dL, n (%)29 (4.1%)21 (3.2%)8 (100%)<0.001
Elevated ALT, n (%)362 (54.3%)360 (54.6%)2 (25%)0.151
Elevated AST, n (%)447 (67%)443 (67.2%)4 (50%)0.112
Elevated ALP, n (%)133 (19.9%)133 (20.2%)0
Prolonged PT, n (%)224 (33.3%)218 (33.1%)6 (75%)0.022
Prolonged aPTT, n (%)159 (23.8%)157 (23.8%)2 (25%)1.000
Thrombocytopenia, n (%)395 (59.2%)393 (59.6%)2 (50%)0.072
MODs, n (%)117 (17.5%)109 (16.5%)8 (100%)<0.001
Haematocrit>20%, n (%)73 (10.9%)68 (10.3%)5 (62.5%)0.001
Rhabdomyolosis, n (%)49 (6.9%)42 (6.4%)7 (87.5%)<0.001
Respiratory failure, n (%)11 (1.5%)9 (1.4%)2 (25%)0.007
  • *p Values were calculated between patients with and without prolonged hospital stay.

  • †DHF refers to all grades including five cases of DSS.

  • AKI, acute kidney injury; ALP, alkaline phosphatase; ALT, alanine aminotransferase; aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase; CKD, chronic kidney disease; DF, dengue fever; DHF, dengue haemorrhagic fever; DM, diabetes mellitus; DSS, dengue shock syndrome; HTN, hypertension; IHD, ischaemic heart disease; MODs, multiple organ dysfunction; PT, prothrombin time; Scr serum creatinine