Variables | Total cohort (n=667) | Non-fatal cases (n=659) | Fatal cases (n=8) | p Value* |
Age (years), mean±SD | 30.7±16.1 | 30.5±1597 | 48.8±25.6 | 0.083 |
Age>40 years, n (%) | 167 (25%) | 161 (24.4%) | 6 (75%) | 0.004 |
Age>60 years, n (%) | 35 (5.2%) | 33 (5.0%) | 2 (25%) | 0.061 |
Male gender, n (%) | 378 (56.7%) | 374 (56.8%) | 4 (50%) | 0.732 |
Secondary infection, n (%) | 73 (10.9%) | 70 (10.6%) | 3 (37.5%) | 0.047 |
Dengue severity, n (%) | ||||
DF, n (%) | 588 (88%) | 582 (88.3%) | 6 (75%) | 0.243 |
DHF†, n (%) | 79 (10.5%) | 77 (11.7%) | 2 (25%) | 0.243 |
Comorbidities, n (%) | ||||
DM, n (%) | 36 (5.4%) | 33 (5.0%) | 3 (37.5%) | 0.007 |
HTN, n (%) | 35 (5.2%) | 33 (5.0%) | 2 (25%) | 0.061 |
CKD, n (%) | 33 (4.9%) | 31 (4.7%) | 2 (25%) | 0.055 |
IHD, n (%) | 25 (3.7%) | 23 (3.5%) | 2 (25%) | 0.033 |
Comorbidities≥2, n (%) | 36 (5.4%) | 33 (5.0%) | 4 (50%) | 0.007 |
AKI, n (%) | 95 (14.2%) | 87 (13.2%) | 8 (100%) | <0.001 |
Scr≥2 mg/dL, n (%) | 29 (4.1%) | 21 (3.2%) | 8 (100%) | <0.001 |
Elevated ALT, n (%) | 362 (54.3%) | 360 (54.6%) | 2 (25%) | 0.151 |
Elevated AST, n (%) | 447 (67%) | 443 (67.2%) | 4 (50%) | 0.112 |
Elevated ALP, n (%) | 133 (19.9%) | 133 (20.2%) | 0 | – |
Prolonged PT, n (%) | 224 (33.3%) | 218 (33.1%) | 6 (75%) | 0.022 |
Prolonged aPTT, n (%) | 159 (23.8%) | 157 (23.8%) | 2 (25%) | 1.000 |
Thrombocytopenia, n (%) | 395 (59.2%) | 393 (59.6%) | 2 (50%) | 0.072 |
MODs, n (%) | 117 (17.5%) | 109 (16.5%) | 8 (100%) | <0.001 |
Haematocrit>20%, n (%) | 73 (10.9%) | 68 (10.3%) | 5 (62.5%) | 0.001 |
Rhabdomyolosis, n (%) | 49 (6.9%) | 42 (6.4%) | 7 (87.5%) | <0.001 |
Respiratory failure, n (%) | 11 (1.5%) | 9 (1.4%) | 2 (25%) | 0.007 |
*p Values were calculated between patients with and without prolonged hospital stay.
†DHF refers to all grades including five cases of DSS.
AKI, acute kidney injury; ALP, alkaline phosphatase; ALT, alanine aminotransferase; aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase; CKD, chronic kidney disease; DF, dengue fever; DHF, dengue haemorrhagic fever; DM, diabetes mellitus; DSS, dengue shock syndrome; HTN, hypertension; IHD, ischaemic heart disease; MODs, multiple organ dysfunction; PT, prothrombin time; Scr serum creatinine