Baseline characteristics of HIV+ WIHS participants who are not ART naïve
| Variables | N (%) or mean ± SD |
| Indices | |
| FFI | |
| 0–2 points | 1143 (82.5) |
| 3–5 points | 242 (17.5) |
| VACS Index score | |
| 0–164 points | 28.9±19.4 |
| CES-D score >16 points | |
| No | 844 (60.9) |
| Yes | 541 (39.1) |
| Outcomes | |
| All deaths | |
| 3 years or less | 73 (5.3) |
| >3–8 years | 111 (8.0) |
| AIDS deaths* | |
| 3 years or less | 39 (2.8) |
| >3–8 years | 35 (2.5) |
| Non-AIDS deaths* | |
| 3 years or less | 32 (2.3) |
| >3–8 years | 45 (3.2) |
| HIV variables | |
| CD4 count (cells/mm3) | |
| >500 | 554 (40.0) |
| 200–499 | 614 (44.3) |
| <200 | 217 (15.7) |
| Viral load (copies/mL) | |
| <500 | 820 (59.2) |
| 500–100 000 | 510 (36.8) |
| >100 000 | 55 (4.0) |
| Haemoglobin (g/dL) | |
| >14 | 209 (15.1) |
| 12–13.9 | 743 (53.6) |
| 10–11.9 | 362 (26.1) |
| <10 | 71 (5.1) |
| FIB4 | |
| <1.45 | 1018 (73.5) |
| 1.45–3.25 | 280 (20.2) |
| >3.25 | 87 (6.3) |
| eGFR (mL/min) | |
| >60 | 1277 (92.2) |
| 45–59.9 | 71 (5.1) |
| 30–44.9 | 15 (1.1) |
| <30 | 22 (1.6) |
| Hepatitis C coinfection | 298 (21.5) |
| Demographic variables | |
| Average age (years, mean ± SD) | 42.6±8.8 |
| Race/ethnicity | |
| White | 324 (23.4) |
| Black | 806 (58.2) |
| Others | 255 (18.4) |
| Education | |
| <High school | 536 (38.7) |
| >High school | 847 (61.2) |
| Mission | 2 (0.1) |
| Smoking history | |
| Not current smoking | 786 (56.8) |
| Current smoking | 599 (43.2) |
| Income | |
| <$12 000 | 669 (48.3) |
| >$12 000 | 668 (48.2) |
| Missing | 48 (3.5) |
| Current alcohol drinking | |
| Abstainer/none | 743 (53.6) |
| Low | 490 (35.4) |
| Moderate | 129 (9.3) |
| High | 23 (1.7) |
| BMI, kg/m2 | |
| BMI<30 | 916 (66.1) |
| BMI>30 (obesity) | 461 (33.3) |
| Missing | 8 (0.6) |
| Current ART use | |
| No | 400 (28.9) |
| Yes (HAART) | 984 (71.0) |
| Missing | 1 (0.1) |
| Prior AIDS-defining illness | |
| No | 802 (57.9) |
| Yes | 583 (42.1) |
| Injection drug use ever | |
| Yes | 305 (22.0) |
| No | 1071 (77.3) |
| Missing | 9 (0.6) |
| Prior pneumonia | |
| No | 1080 (78.0) |
| Yes | 305 (22.0) |
| Current/prior hypertension | |
| No | 964 (69.6) |
| Yes | 421 (30.4) |
| History of diabetes | |
| No | 1195 (86.3) |
| Yes | 190 (13.7) |
| Prior cancer diagnosis | |
| No | 1220 (88.1) |
| Yes | 165 (11.9) |
*For some deaths, cause of death could not be classified as AIDS/non-AIDS, thus the numbers of AIDS + non-AIDS deaths do not sum to total deaths.
ART, antiretroviral therapies; BMI, body mass index; CES-D, Center for Epidemiologic Studies-Depression; eGFR, estimated glomerular filtration rate; FFI, Fried Frailty Index; HAART, highly active antiretroviral therapy; HIV+, HIV-infected; VACS, Veterans Aging Cohort Study; WIHS, Women’s Interagency HIV Study.