Overview of the longitudinal assessments during risk periods and following onset of bipolar disorder in the four substudies of the BIO study
| Course | Healthy first-generation relatives | First episode | Remission | First relapse | Remission | Second relapse | Others |
| BIO-1 | x | x | x | x | x | x | x |
| BIO-2 | x | x | x | x | x | x | x |
| BIO-3 | x | x | x | x | |||
| BIO-4 | x | x | x | x | x | x | x |
BIO-1: Peripheral blood-based biomarker in bipolar disorder.
BIO-2: Smartphone-based electronic biomarker in bipolar disorder.
BIO-3: Neurocognitive and brain imaging signatures in bipolar disorder.
BIO-4: At risk or prodromal phase for bipolar disorder.
BIO, Bipolar Illness Onset study.