Schedule of events
| PICU admission OR prior to extubation | Study entry | Hourly for first 6 hours | At 12, 24, 36, 48 and 72 hours until end of treatment | Hospital discharge (or death) | At day 28 | |
| Screening for eligibility | x | |||||
| Informed consent and consent questionnaire | x | x* | ||||
| Randomisation | x | |||||
| Treatment (HFNC or CPAP) | x | x | ||||
| Physiology | x | x | ||||
| COMFORT score | x | x | ||||
| PSS:PICU Questionnaire (at 24 hours only) | x | |||||
| Hospital stay data | x | |||||
| Safety monitoring | x |
*Deferred consent will be sought as soon as practically possible, usually within 48 hours.
CPAP, continuous positive airway pressure; HFNC, high-flow nasal cannula; PSS, Parental Stressor Scale; PICU, Paediatric Intensive Care Unit.