Eligibility criteria for inclusion in systematic review
| Inclusion criteria | Exclusion criteria | |
| Population | Age ≥18 years | Age <18 years |
| Intervention | Invasive positive pressure ventilation | Chronic ventilation |
| Reference standard | Objective measure of sedation depth | None |
| Outcomes | Mortality Hospital length of stay Intensive care unit length of stay Time to extubation Delirium Incidence of tracheostomy | None |
| Study design | Randomised controlled trials Prospective cohort studies Retrospective cohort studies Cross-sectional studies Before-after trials | Correspondences Editorials Non-human studies |