Procoagulant biomarkers by chronic kidney disease status.
| Variables | Healthy control | CKD 3 | CKD 4 | CKD 5 | p | p† |
| Platelet (109/L) | 237.2±47.4 | 214.8±65.0 | 214.0±52.8 | 195.8±58.6 | 0.156 | 0.284 |
| ADPLTA (%)& | 64.6±4.8♦ | 67.3±8.6♦ | 70.1±8.6 | 74.7±8.2* | 0.041 | 0.738 |
| Factor V (%) | 113.6±26.1 | 98.4±31.9 | 106.7±36.9 | 103.4±33.3 | 0.533 | 0.640 |
| Factor VII (%) | 74.2±14.3♦ | 94.5±18.0*♦ | 104.2±17.9* | 108.4±27.2* | <0.001 | 0.050 |
| Factor VIII (%) | 86.5±22.3♦ | 115.3±25.1*♦ | 130.5±27.6* | 139.9±33.0* | <0.001 | <0.001 |
| VWF:Ag (%) | 103.1±42.4♦ | 124.7±51.4♦ | 158.9±49.9* | 181.8±45.6* | <0.001 | 0.011 |
| vWF:RCo (%) | 99.8±29.9♦ | 115.5±43.2♦ | 150.2±45.1* | 168.2±41.5* | <0.001 | 0.004 |
| Fibrinogen (g/L) | 3.0±0.8♦ | 3.1±0.7♦ | 3.8±0.8*♦ | 4.5±1.1* | <0.001 | 0.006 |
| Protein C (%) | 105.3±17.0♦ | 99.4±18.6♦ | 93.5±17.9 | 86.6±15.2* | 0.024 | 0.736 |
| Protein S (%) | 76.8±23.2 | 88.2±24.6 | 94.5±20.7 | 99.5±25.5 | 0.076 | 0.584 |
| AT III (%) | 99.5±9.3 | 103.8±12.2 | 103.8±11.7 | 103.1±11.8 | 0.658 | 0.189 |
| D-dimer (ng/ml) | 257±116♦ | 425±277♦ | 505±320*♦ | 842±496* | <0.001 | 0.039 |
| APTT (s) | 39.0±4.5 | 37.7±3.2 | 37.5±3.7 | 39.0±4.2 | 0.286 | 0.187 |
| PT (s) | 13.4±0.6 | 13.5±0.6 | 13.5±0.6 | 13.7±0.6 | 0.320 | 0.192 |
ADPLTA (%): platelet aggregation records were available in 49 CKD cases (15 cases in CKD 3 stage; 21 cases in CKD 4 stage; 13 cases in CKD 5 stage) and 9 healthy controls.
*p<0.05 versus control group;♦p<0.05 versus CKD 5 group.
†p Values for the adjusted model. Data are adjusted for age, sex, history of diabetes, history of coronary heart disease, smoking status, mean arterial pressure, body mass index, haemoglobin, serum albumin, cholesterol, triglyceride and urine albumin-to-creatinine ratio.
APTT, activated partial thromboplastin time; AT III, antithrombin III; CKD, chronic kidney disease; LTA, light transmittance aggregometry; PT, prothrombin time; vWF:Ag, von Willebrand factor antigen; vWF:RCo, vWF ristocetin cofactor activity.