Planned outcome measures
| α2agonist combined | Clonidine | Dexmedetomidine | Control | |
| Proportion of time adequately sedated (ratio vs control) | ||||
| Proportion of time potentially undersedated (ratio vs control) | ||||
| Proportion of time potentially oversedated (ratio vs control) | ||||
| Morphine use (μg/kg/24 hours) | ||||
| Midazolam use (μg /kg/24 hours) | ||||
| Number of morphine boluses (N/24 hours) | ||||
| Difference between morphine infusion baseline and average rate (μg/kg/24 hours) | ||||
| Number of midazolam boluses (N/24 hours) | ||||
| Number of chloral hydrate boluses (N/24 hours) | ||||
| Number of paracetamol boluses (N/24 hours) | ||||
| Duration of mechanical ventilation (days) | ||||
| Ventilator-free days | ||||
| Paediatric intensive care unit stay |