Distribution of neuropsychiatric events in the international cohort
| First, n (%) | Following, n (%) | All, n (%) | |
| PNS and CNS involvement | 243 (100) | 93 (100) | 336 (100) |
| CNS involvement | 202 (82.3) | 83 (89.2) | 285 (84.8) |
| Mood disorder | 43 (17.7) | 12 (12.9) | 55 (16.4) |
| Headache | 35 (14.4) | 15 (16.1) | 50 (14.9) |
| CVD | 33 (13.6) | 5 (5.4) | 38 (11.3) |
| Seizures | 22 (9.1) | 12 (12.9) | 34 (10.1) |
| Anxiety | 16 (6.6) | 2 (2.1) | 18 (5.4) |
| Cognitive dysfunction | 13 (5.3) | 20 (21.5) | 33 (9.8) |
| Psychosis | 11 (4.5) | 6 (6.5) | 17 (5.1) |
| MS-like syndrome | 9 (3.7) | 1 (1.08) | 10 (3) |
| Myelopathy | 8 (3.3) | 4 (4.3) | 12 (3.6) |
| Movement disorder | 5 (2.1) | 1 (1.1) | 6 (1.8) |
| Acute confusional state | 5 (2.1) | 3 (3.2) | 8 (2.4) |
| Aseptic meningitis | 2 (0.8) | 2 (2.1) | 4 (1.2) |
| PNS involvement | 41 (17.7) | 10 (10.8) | 51 (15.2) |
| Cranial neuropathy | 15 (6.2) | 3 (3.2) | 18 (5.4) |
| Polyneuropathy | 10 (4.1) | 4 (4.3) | 14 (4.2) |
| Myasthenia gravis | 9 (3.7) | – | 9 (2.7) |
| Mononeuropathy | 4 (1.6) | 2 (2.1) | 6 (1.8) |
| Guillain-Barré syndrome | 3 (1.2) | – | 3 (0.9) |
| Autonomic neuropathy | – | – | – |
| Plexopathy | – | 1 (1.1) | 1 (0.3) |
| Major/minor | 148/95 (60.9/39.1) | 64/29 (68.8/31.2) | 212/124 (63.1/36.9) |
| Focal/diffuse | 109/134 (44.9/55.1) | 61/32 (65.6/34.4) | 170/166 (50.6/49.4) |
| Central/peripheral | 202/41 (83.1/16.9) | 83/10 (89.2/10.8) | 287/49 (85.4/14.6) |
CNS, central nervous system; CVD, cerebrovascular disease; MS, multiple sclerosis; PNS, peripheral nervous system.