ACE genotype and salt intake interaction explorations by logistic model and generalised partially linear tree-based regression model
| Logistic Model | GPLTR Model | ||||
| Terms in the model | Multi-adjusted OR* (95% CI) | p value | Nodes in the model | Multi-adjusted OR* (95% CI) | p value |
| Men (ROC=0.747) | Men (ROC=0.809) | ||||
| Salt intake, g/day | 1.00 (0.99 to 1.03) | 0.415 | Node 1: Salt intake ≥19.5 and ACE (II) | 1.00 | |
| ACE (ID+DD vs II) | 1.33 (0.66 to 2.65) | 0.426 | Node 2: Salt intake ≥19.5 and ACE (ID+DD) | 3.99 (1.55 to 10.26) | 0.004 |
| ACE (ID+DD vs II)×salt intake | 0.99 (0.96 to 1.02) | 0.464 | Node 3: 15.3 ≤ salt intake < 19.5 | 0.93 (0.41 to 2.09) | 0.860 |
| Women (ROC=0.839) | Women (ROC=0.839) | ||||
| Salt intake, g/day | 0.99 (0.94 to 1.03) | 0.523 | Node 1: Salt intake <20.1 and ACE (II) | 1.00 | |
| ACE (ID+DD vs II) | 0.20 (0.07 to 0.59) | 0.003 | Node 2: Salt intake < 20.1 and ACE (ID+DD) | 0.55 (0.34 to 0.89) | 0.014 |
| ACE (ID+DD vs II) × salt intake | 1.07 (1.01 to 1.13) | 0.027 | Node 3: 20.1 ≤ salt intake | 1.26 (0.70 to 2.25) | 0.444 |
*Men adjusted for age, education, body mass index, drinking and fasting blood glucose; women adjusted for age, education, body mass index, occupation and fasting blood glucose.
GPLTR, generalized partially linear tree-based regression; ROC, receiver operating characteristic curve.