Study | Number of patients enrolled | Comparator | Patients age (mean) | % females | ROA >50%* | Pain measure† | Baseline mean intervention (SD) | Baseline mean control (SD) | Function measure† | Baseline mean (SD) | Baseline mean control (SD) |
---|---|---|---|---|---|---|---|---|---|---|---|
Chang, 199334 | 34 | Close needle joint lavage | 62.8 | 71.6 | Y | AIMS pain | 65 (20) | 61 (21) | AIMS physical function | 23 (16) | 17 (10) |
Gauffin, 201435 | 150 | Exercise therapy | 54.5 | 27.3 | N | KOOS pain | 55 (18) | 58 (18) | KOOS ADL | 65 (18) | 68 (22) |
Herrlin, 2007,36 201337 | 96 | Exercise therapy | 54 | 38.9 | N | KOOS pain | 56 (18) | 63 (21) | KOOS ADL | 68 (21) | 73 (20) |
Katz, 201338 | 351 | Exercise therapy | 58.4 | 56.7 | Y | KOOS pain | 54 (16) | 53 (16) | WOMAC function | 37 (18) | 38 (18) |
Kirkley, 200839 | 188 | Exercise therapy | 59.6 | 62.9 | Y | WOMAC pain | 52 (21) | 43 (24) | WOMAC function | 51 (21) | 43 (23) |
Kise, 201613 | 140 | Exercise therapy | 49.6 | 39 | Y | KOOS pain | 68 (15) | 63 (21) | KOOS ADL | 80 (16) | 75 (22) |
Moseley, 200240 | 119 | Sham surgery | 52.8 | 5 | Y | SF-36 body pain | 39 (19) | 38 (18) | SF-36 physical function | 42 (22) | 47 (23) |
Osteras, 201241 | 17 | Exercise therapy | 49.7 | 23.6 | N | VAS | 37 (10) | 35 (17) | NM | − | − |
Saeed, 201542 | 120 | Hyaluronic acid injection | NR | 81.7 | NR | Knee society score‡ | NR | NR | Knee society score‡ | NR | NR |
Sihvonen, 201343 | 146 | Sham surgery | 52 | 39 | N | VAS | 58 (20) | 61 (20) | Lysholm knee score‡ | NA | NA |
Stensrud, 201544 | 82 | Exercise therapy | 48.9 | 35.4 | N | Ordinal scale | NR | NR | Ordinal scale | NR | NR |
Vermesan, 201345 | 114 | Steroid injection | 58.4 | 79.2 | NR | Oxford knee score‡ | NR | NR | Oxford knee score‡ | NR | NR |
Yim, 201346 | 108 | Exercise therapy | 56.8 | 79.4 | N | VAS | 52 (18) | 49 (15) | Lysholm score‡ | NA | NA |
*Based on Kellgren-Lawrence classification. Grades 2–4 were considered radiographic OA.
†All measures were converted to 0–100 scale. Higher scores mean less pain and better function.
‡Instrument combines pain and function together.
ADL, Function in Daily Living; AIMS, Arthritis Impact Measurement Scale; KOOS, Knee injury and Osteoarthritis Outcome Score; NA, not applicable; NM, not measured; NR, not reported; ROA, Radiographic osteoarthritis; SF-36, 36-Item Short-Form Survey; VAS, Visual Analogue Scale; WOMAC, Western Ontario and McMaster Universities Arthritis Index.