Unadjusted outcomes by maximum serum osmolarity categories in patients with or without respiratory admission diagnosis
| Outcome | Patients without respiratory disease (n=14 736) (osmolaritymax, mmol/L) | p1 p2 | Patients with respiratory disease (n=1750) (osmolaritymax, mmol/L) | p1 p2 | ||||
| <289 (n=246) | 290–309 (n=8653) | ≥310 (n=5837) | <289 (n=40) | 290–309 (n=816) | ≥310 (n=894) | |||
| Hospital mortality (n (%)) | 22 (8.9) | 399 (4.6) | 1250 (21.4) | 0.002 <0.001 | 9 (22.5) | 113 (13.8) | 258 (30.3) | 0.13 <0.001 |
| ICU mortality (n (%)) | 15 (6.1) | 315 (3.6) | 991 (7.9) | 0.04 <0.001 | 8 (20) | 91 (11.1) | 222 (24.8) | 0.09 <0.001 |
| Hospital LOS (days) median (IQR) | 5 (3–8) | 6 (4–10) | 11 (6–19) | <0.001 <0.001 | 5 (3–8) | 7 (4–11) | 11 (6–19) | 0.02 <0.001 |
| ICU LOS (days) median (IQR) | 1.8 (1.3–2.6) | 2.1 (1.3–3.3) | 3.8 (2.0–8.5) | <0.001 <0.001 | 2.1 (1.3–3) | 2.5 (1.5–4.7) | 5.0 (2.0–10.8) | 0.04 <0.001 |
| AKI (n (%)) | 50 (20.3) | 2398 (27.7) | 3467 (59.3) | 0.01 <0.001 | 8 (20) | 261 (31.9) | 532 (59.5) | 0.11 <0.001 |
| Max SOFA score median (IQR) | 4 (2–7) | 6 (3–8) | 8 (5–11) | <0.001 <0.001 | 4 (2–7.5) | 5 (3–8) | 8 (6–11) | 0.38 <0.001 |
| Vasopressin (n (%)) | 2 (0.8) | 150 (1.70) | 527 (9.0) | 0.27 <0.001 | 1 (2.5) | 13 (1.6) | 71 (7.9) | 0.66 <0.001 |
P1 represents the p value of comparisons between the group with osmolaritymax <289 mmoL/L and the group with osmolaritymax290–309 mmoL/L, and p2 represents the p value of comparisons between the groups with osmolaritymax ≥310 and 290–309 mmoL/L. osmolaritymax, maximum plasma osmolarity during ICU stay.
AKI, acute kidney injury; ICU, intensive care unit; LOS, length of stay; SOFA, sequential organ failure assessment.