Linking mechanisms to outcomes
| Mechanisms | Outcomes | |||||
| All (n=261) | Successful deprescribing (n=92) | Intent but failed deprescribing (n=75) | No attempt to deprescribe (n=94) | Successful and failed intent versus no attempt* p value/risk difference (95% CI) | Successful completion versus failed intent to deprescribe p value/risk difference (95% CI) | |
|---|---|---|---|---|---|---|
| Increased motivation | ||||||
| Change in knowledge: | ||||||
| Baseline knowledge (/4), mean (SD) | 0.85 (0.99) | 0.97 (1.08) | 0.87 (0.97) | 0.71 (0.90) | 0.10 | 0.54 |
| Postintervention knowledge (/4), mean (SD) | 1.92 (1.40) | 2.64 (1.23) | 2.01 (1.34) | 1.13 (1.20) | 0.00* | 0.00* |
| Increase in knowledge postintervention, n (%) | 156 (59.8) | 80 (86.9) | 55 (73.3) | 21 (22.3) | 58.5 (47.0 to 67.4)* | 13.6 (1.6 to 25.9)* |
| Beliefs about benzodiazepines | ||||||
| Baseline belief about necessity† (/25), mean score (SD) | 13.8 (3.4) | 13.0 (0.3) | 14.3 (0.4) | 14.1 (0.4) | 0.23 | 0.01* |
| Postintervention belief about necessity†, mean score (SD) | 12.58 (3.32) | 11.07 (0.30) | 12.55 (0.32) | 14.05 (0.35) | 0.00* | 0.10 |
| Participants with a decrease in score about necessity postintervention, n (%) | 138 (52.8) | 75 (81.5) | 47 (62.7) | 16 (17.4) | 56.0 (44.6 to 64.8)* | 18.9 (5.3 to 32.0)* |
| Baseline concern†, (/25), mean score (SD) | 13.4 (2.7) | 13.4 (0.3) | 14.1 (0.3) | 12.9 (0.3) | 0.00* | 0.01* |
| Postintervention concern†, mean score (SD) | 14.42 (3.41) | 15.60 (0.37) | 15.34 (0.36) | 12.56 (0.28) | 0.00* | 0.62 |
| Participants with increased concern postintervention, n (%) | 138 (52.8) | 70 (76.1) | 59 (78.7) | 9 (9.7) | 67.7 (57.3 to 74.9)* | −2.6 (−15.0 to 10.4) |
| Risk perception: | ||||||
| Participants perceiving increased risk postintervention, n (%) | 118 (44.8) | 51 (55.4) | 45 (60.0) | 21 (22.3) | 35.1 (23.1 to 45.4)* | −4.6 (−19.1 to 10.4) |
| Building capacity | ||||||
| Self-efficacy for tapering | ||||||
| Baseline self-efficacy (/100), mean (SD) | 37.8 (35.7) | 47.3 (34.6) | 35.0 (37.4) | 31.0 (33.6) | 0.03* | 0.02* |
| Postintervention increase in self-efficacy score, mean change (SD) | 25.44 (42.78) | 35.78 (36.80) | 36.03 (44.63) | 6.00 (40.93) | 0.00* | 0.97 |
| Participants with increased self-efficacy postintervention, n (%) | 145 (55.5) | 70 (76.1) | 57 (76.0) | 18 (19.1) | 56.9 (45.4 to 65.8)* | 0 (−12.6 to 13.3) |
| Creating opportunity | ||||||
| Outreach to a healthcare professional: | ||||||
| Discussed with physician, n (%) | 103 (39.5) | 42 (45.6) | 38 (50.6) | 23 (25.0) | 23.4 (11.3 to 34.1)* | −5.0 (−19.8 to 10.0) |
| Discussed with pharmacist, n (%) | 56 (20.1) | 25 (27.1) | 22 (28.9) | 9 (9.7) | 18.6 (8.7 to 27.1)* | −2.2 (−15.9 to 11.3) |
*Level of significance, p<0.05.
†As some participants selected more than one condition, total does not equal 100%.
Independent sample t-test for continuous variables, χ2 for categorical variables.