Outcome measures to be collected at various time points in the study
| Outcome | Measure | Hypothesis | Analysis | T0 | T1 | T2 |
|---|---|---|---|---|---|---|
| Primary outcome | ||||||
| Drug burden | DBI* | Decrease | Paired t-test/WSR* test | x | x | x |
| Secondary outcomes | ||||||
| Quality of health measures, cognition and adverse effects | ||||||
| Quality of life | EQ-5D-5L* | Remain the same/improve | Paired t-test/WSR* test | x | x | |
| Cognition | InterRAI-LTCF* | Remain the same or deteriorate | Paired t-test/WSR* test | x | x | x |
| Adverse effects caused by psychotropics | UKU-SERS* | Decrease | Paired t-test/WSR* test | x | x | x |
| Number of falls in the past 6 months | Resident records | Remain the same or decrease | Paired t-test/WSR* test | x | x | |
| Specific morbidities | ||||||
| Depression | GDS InterRAI-DRS | Remain the same | Paired t-test/WSR* test | x | x | x |
| Pain | InterRAI Pain Scale | Remain the same or be improve | Paired t-test/WSR* test | x | x | |
| Aggressive behaviour | InterRAI Aggressive Behaviour Scale | Remain the same or improve | Paired t-test/WSR* test | x | x | |
| Deprescribing recommendations | ||||||
| Proportion of recommendations taken up by GPs | χ2 | |||||
| Proportion of recommendations taken up by patients | χ2 | |||||
| Medicines | ||||||
| Change in the mean number of medicines prescribed | Remain the same or decrease | Paired t-test/WSR* test | x | x | ||
DBI, Drug Burden Index; DRS, Depression Rating Scale; EQ-5D-5L, EuroQoL 5-dimension 3-level descriptive system of health-related quality of life; GDS, Geriatric Depression Scale; GP, general practitioner; InterRAI-LTCF, an assessment system that informs and guides comprehensive care and service planning and can be used to assess persons with chronic needs for care; LTCF, Long Term Care Facilities; T0, participant enrolment time; T1, 3 months after participant enrolment; T2, 6 months after participant enrolment; UKU-SERS, UKU-Side Effect Rating Scale is a scale that documents unwanted effects of psychotropics using a semistructured interview; WSR, Wilcoxon signed-rank test.