Mean change from baseline (95% CI) | Mean treatment difference (95% CI) | p Value | Number of participants confirmed | ||
---|---|---|---|---|---|
Usual care | Exercise programme | ||||
MHQ overall hand function | |||||
4 months | 3.27 (1.15 to 5.39) | 9.27 (7.19 to 11.34) | 6.24 (3.56 to 8.92)*** | <0.0001 | 320 |
12 months | 3.19 (0.79 to 5.59) | 7.18 (5.02 to 9.33) | 3.91 (0.71 to 7.10)* | 0.0171 | 324 |
Extended follow-up | 1.97 (−0.45 to 4.39) | 3.76 (1.50 to 6.02) | 1.52 (−1.71 to 4.76) | 0.3567 | 327 |
MHQ ADL (both hands) | |||||
4 months | 3.37 (0.94 to 5.79) | 8.29 (5.61 to 10.96) | 5.07 (1.73 to 8.42)** | 0.0032 | 319 |
12 months | 2.53 (−0.12 to 5.18) | 5.34 (2.71 to 7.97) | 2.83 (−0.90 to 6.56) | 0.1375 | 323 |
Extended follow-up | 2.34 (0.03 to 4.66) | 3.15 (0.30 to 6.01) | 0.72 (−2.88 to 4.32) | 0.6948 | 324 |
MHQ work | |||||
4 months | 4.91 (1.91 to 7.91) | 8.26 (5.47 to 11.04) | 3.04 (−0.96 to 7.04) | 0.1370 | 316 |
12 months | 2.97 (−0.05 to 5.99) | 7.70 (4.73 to 10.68) | 4.44 (0.30 to 8.57)* | 0.0363 | 323 |
Extended follow-up | 5.81 (2.97 to 8.65) | 7.76 (4.67 to 10.84) | 2.06 (−2.10 to 6.22) | 0.3318 | 315 |
SF 12 Mental Component Score (MCS) | |||||
4 months | 0.70 (−0.62 to 2.02) | 1.09 (−0.18 to 2.37) | 0.51 (−1.16 to 2.18) | 0.5488 | 319 |
12 months | 0.21 (−1.21 to 1.64) | 2.12 (0.54 to 3.69) | 1.63 (−0.22 to 3.49) | 0.0857 | 322 |
Extended follow-up | 0.21 (−1.23 to 1.66) | 0.27 (−1.25 to 1.78) | 0.22 (−1.71 to 2.15) | 0.8252 | 326 |
SF 12 Physical Component Score (PCS) | |||||
4 months | 0.62 (−0.39 to 1.63) | 1.84 (0.65 to 3.02) | 1.37 (−0.12 to 2.86) | 0.0719 | 319 |
12 months | −0.09 (−1.24 to 1.06) | 0.76 (−0.39 to 1.92) | 0.72 (−0.79 to 2.23) | 0.3519 | 321 |
Extended follow-up | −0.51 (−1.66 to 0.64) | 0.19 (−1.16 to 1.54) | 0.50 (−1.24 to 2.25) | 0.5720 | 326 |
EQ-5D health state | |||||
4 months | 0.0 (−0.03 to 0.04) | 0.06 (0.02,0.09) | 0.03 (−0.01 to 0.07) | 0.1654 | 319 |
12 months | 0.02 (−0.02 to 0.05) | 0.04 (0.00 to 0.07) | 0.00 (−0.04 to 0.05) | 0.8239 | 0.322 |
Extended follow-up | −0.01 (−0.05 to 0.02) | −0.01 (−0.05 to 0.03) | −0.01 (−0.06 to 0.04) | 0.6893 | 324 |
Pain troublesomeness score† | |||||
4 months | −4.79 (−7.76 to −1.82) | −5.57 (−8.25 to −2.90) | −2.51 (−6.22 to 1.21) | 0.1872 | 315 |
12 months | −4.68 (−7.83 to −1.53) | −5.03 (−8.16 to −1.90) | −1.58 (−5.65 to 2.48) | 0.4454 | 322 |
Extended follow-up | −3.79 (−6.93 to −0.64) | 0.20 (−2.98 to 3.38) | 3.23 (−0.83 to 7.28) | 0.1199 | 326 |
Self-efficacy—confidence to manage their condition | |||||
4 months | 2.38 (−0.15 to 4.62) | 6.58 (3.74 to 9.42) | 3.41 (0.5 to 6.29)* | 0.0209 | 319 |
12 months | 1.30 (−1.32 to 3.92) | 5.46 (2.29 to 8.62) | 3.19 (0.71 to 6.98) | 0.1113 | 321 |
Extended follow-up | 0.22 (−2.34 to 2.78) | 2.96 (0.03 to 5.90) | 2.30 (−1.20 to 5.79) | 0.1988 | 323 |
*p<0.05; ** p<0.01; ***p<0.001.
†Higher score, more pain.
ADL, activities of daily living; EQ-5D, EuroQol five dimensions questionnaire; MHQ, Michigan Hand Outcome Questionnaire.