Patients’ characteristics by UA levels
| Total patients | UA baseline >8 mg/dL | UA baseline ≤8 mg/dL | p Value | |
|---|---|---|---|---|
| Number of patients | 371 | 119 (32.10%) | 252 (67.9%) | <0.001* |
| Sex, men | 163 (43.94%) | 65 (54.62%) | 98 (38.89%) | 0.006* |
| Age (years) | 55.72±15.99 | 52.41±16.43 | 57.28±15.57 | 0.006* |
| Body mass index (kg/m2) | 22.77±3.82 | 23.15±3.77 | 22.6±3.84 | 0.195 |
| Follow-up time (months) | 29.97±38.32 | 29.40±38.21 | 31.17±38.35 | 0.818 |
| Assistant | ||||
| Yes | 196 (52.83%) | 68 (57.14%) | 128 (50.79%) | 0.302 |
| Comorbid conditions | ||||
| Diabetes mellitus | 117 (31.54%) | 38 (31.93%) | 79 (31.35%) | 1.000 |
| Hypertension | 305 (82.21%) | 98 (82.35%) | 207 (82.14%) | 1.000 |
| Coronary artery disease | 58 (15.63%) | 18 (15.13%) | 40 (15.87%) | 0.975 |
| Cerebrovascular disease | 32 (8.63%) | 12 (10.08%) | 20 (7.94%) | 0.624 |
| Peripheral artery disease | 8 (2.16%) | 3 (2.52%) | 5 (1.98%) | 1.000 |
| Medications | ||||
| ACE inhibitor/ARB | 245 (66.04%) | 82 (68.91%) | 163 (64.68%) | 0.494 |
| Hypouricaemic agents (allopurinol) | 89 (23.99%) | 33 (27.73%) | 56 (22.22%) | 0.303 |
| Diuretics | 200 (53.91%) | 70 (58.82%) | 130 (51.59%) | 0.233 |
| Calcium channel blocker | 265 (71.43%) | 89 (74.79%) | 176 (69.84%) | 0.389 |
| β-blocker | 79 (21.29%) | 29 (24.37%) | 50 (19.84%) | 0.391 |
| PD-related parameters | ||||
| Icodextrin use | 114 (30.73%) | 37 (31.09%) | 77 (30.56%) | 1.000 |
| Balance dialysate | 23 (6.2%) | 4 (3.36%) | 19 (7.54%) | 0.184 |
| Residual renal function (mL/min/1.73 m2) | 2.53±2.68 | 2.77±2.86 | 2.45±2.59 | 0.525 |
| D/P creatinine at 4 hours | 0.67±0.11 | 0.67±0.11 | 0.67±0.11 | 0.619 |
| Ultrafiltration (L/day) | 0.34±0.75 | 0.44±0.79 | 0.3±0.79 | 0.023* |
| 24-hour urine volume (L) | 0.85±0.82 | 0.8±0.7 | 0.86±0.87 | 0.402 |
| Kt/V for PD (weekly Kt/V) | 1.48±0.47 | 1.48±0.39 | 1.48±0.49 | 0.946 |
| Total weekly Kt/V | 2.08±0.56 | 2.03±0.49 | 2.12±0.56 | 0.166 |
| nPNA (g/kg/day) | 1.04±0.41 | 1.08±0.37 | 1.02±0.4 | 0.067 |
| Exit-site infection (per 100 patient-years) | 0.29±0.66 | 0.36±0.66 | 0.26±0.66 | 0.162 |
| Tunnel infection rate (per 100 patient-years) | 0.01±0.05 | 0.01±0.06 | 0.01±0.05 | 0.495 |
| Peritonitis rate (per year) | 0.18±0.35 | 0.22±0.4 | 0.16±0.32 | 0.109 |
| Number of exchanges per day | 4±0.22 | 4±0.33 | 4±0.19 | 0.197 |
| Laboratory data | ||||
| Serum albumin (g/dL) | 3.52±0.74 | 3.4±0.68 | 3.58±0.8 | 0.593 |
| BUN (mg/dL) | 83.83±30.29 | 95±29.86 | 78.53±28.27 | <0.001* |
| Calcium (mg/dL) | 8.3±0.98 | 8.25±0.94 | 8.3±0.92 | 0.047* |
| Phosphorus (mg/dL) | 5.4±1.89 | 5.85±1.72 | 5.24±1.71 | <0.001* |
| Calcium phosphate product (mg2/dL2) | 43.89±14.45 | 46.07±13.9 | 42.63±13.97 | 0.002* |
| Creatinine (mg/dL) | 9.5±3.87 | 10.1±4.72 | 9.22±3.45 | 0.009* |
| Ferritin (ng/mL) | 266.8±341.85 | 263.06±395.35 | 270.81±320.77 | 0.874 |
| GPT (U/L) | 16±11.06 | 16.33±10.95 | 15.58±11.36 | 0.675 |
| Haemoglobin (g/dL) | 8.4±1.34 | 8.21±1.44 | 8.49±1.29 | 0.07 |
| UA (mg/dL) | 7.33±1.92 | 9.1±1.49 | 6.72±1.25 | <0.001* |
Values are expressed as mean±SD or number (percentage).
*p Value <0.05.
ARB, angiotensin II receptor blocker; BUN, blood urea nitrogen; PD, peritoneal dialysis; UA, uric acid.