Baseline characteristics of the study patients by 50% stenosis status
| No CAD | Obstructive CAD | p Value | Total | N missing | Genders* | |
|---|---|---|---|---|---|---|
| n=2761 (56%) | n=2127 (44%) | n=4888 | n=1251 | |||
| Sex (male) | 53% | 74% | <0.001 | 62% | 0 | 70% |
| Age (years), ms | 63 (11) | 66 (10) | <0.001 | 64 (11) | 0 | 64 (10) |
| Age (years), range | 18 to 89 | 26 to 87 | 18 to 89 | 0 | 18 to 93 | |
| Chest pain | 56% | 68% | <0.001 | 61% | 0 | 53% |
| Diabetes mellitus | 13% | 19% | <0.001 | 15% | 0 | 18% |
| Hypertension | 73% | 80% | <0.001 | 76% | 0 | 67% |
| Ever smoking | 43% | 49% | <0.001 | 46% | 640 | 36% |
| Body mass index (kg/m2), ms | 27.1 (4.5) | 27.0 (4.0) | 0.54 | 27.0 (4.3) | 60 | 28 (NA) |
| Family history of myocardial infarction | 22% | 21% | 0.75 | 22% | 0 | |
| Total cholesterol (mg/dL), ms | 199 (44) | 200 (45) | 0.23 | 199 (44) | 257 | |
| HDL cholesterol (mg/dL), ms | 59 (18) | 53 (15) | <0.001 | 56.6 (17.2) | 312 | |
| LDL cholesterol (mg/dlL), ms | 126 (36) | 131 (39) | <0.001 | 128 (37) | 310 | |
| Triglycerides (mg/dL), mi | 120 (87; 166) | 130 (96; 181) | <0.001 | 125 (90; 173) | 263 | |
| Fibrinogen (mg/dL), mi | 352 (285; 424) | 370 (305; 460) | <0.001 | 360 (293; 441) | 119 | |
| C reactive protein >1.00 mg/dL | 11% | 17% | <0.001 | 14% | 96 | |
| Prothrombin time (%), ms | 103 (13) | 104 (12) | 0.07 | 104 (13) | 76 | |
| Thrombocytes (×1000 U/µL), ms | 236 (62) | 232 (68) | 0.08 | 234 (64) | 79 | |
| Haemoglobin (g/dL), ms | 14.3 (1.5) | 14.4 (1.5) | 0.02 | 14.4 (1.5) | 60 | |
| Creatinine (mg/dL), ms | 0.98 (0.46) | 1.07 (0.59) | <0.001 | 1.02 (0.52) | 53 | |
| eGFR (mL/min/1.73 m2), ms | 78.2 (20.0) | 76.0 (20.5) | <0.001 | 77.2 (20.2) | 53 | |
| γ-glutamyltransferase (U/L), mi | 30 (19; 50) | 33 (22; 54) | <0.001 | 31 (20; 51) | 165 | |
| Uric acid (mg/dL), ms | 6.12 (1.71) | 6.49 (1.67) | <0.001 | 6.28 (1.71) | 428 | |
| Urea (mg/dL), mi | 34.1 (28.3; 41.9) | 36.4 (29.9; 44.4) | <0.001 | 35.0 (28.9; 43.0) | 128 | |
| Coronary artery disease | 0 | |||||
| Non-obstructive | 100% | 0% | 56% | 40% | ||
| Moderate (50–70%) | 0% | 11% | 5% | 45% | ||
| Severe (≥70% or LM≥50%) | 0% | 89% | 39% | 16% |
*Comparable data from the hospitals with a high prevalence setting of the study by Genders et al.3
CAD, coronary artery disease; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; LDL, low-density lipoprotein; LM, left main artery; mi, median (IQR); ms, mean (SD); NA, SD not available.