Characteristics of studies included in meta-analysis (n=15)
| Study | Published year | Country | Number of participants | Age at enrolment in the study (months) | Age at follow-up (years) | Outcome | Effect estimate (95% CI) | NOS |
|---|---|---|---|---|---|---|---|---|
| Kotaniemi-Syrjänen et al40 (rhinovirus wheezing illnesses study) | 2003 | Finland | 100 | <24 | 6–8 | Asthma | OR 4.14 (1.02 to 16.77) | 7 |
| Hyvärinen et al18 (rhinovirus wheezing illnesses study) | 2005 | Finland | 100 | <24 | 11–13 | Asthma | OR 1.41 (0.4 to 4.94) | 7 |
| Ruotsalainen et al35 (rhinovirus wheezing illnesses study) | 2013 | Finland | 100 | <24 | 15–18 | Asthma | OR 9.23 (2.17 to 39.31) | 7 |
| Lemanske et al39 (COAST study) | 2005 | USA | 289 | Newborns | 3 | Wheezing | OR 10 (4.1 to 26) | 8 |
| Jackson et al19 (COAST study) | 2008 | USA | 289 | Newborns | 6 | Asthma | OR 2.8 (1.4 to 5.6) | 8 |
| Rubner et al36 (COAST study) | 2016 | USA | 289 | Newborns | 13 | Asthma | OR 3.3 (1.5 to 7.1) | 8 |
| Kusel et al37 (respiratory viral infections study) | 2007 | Australia | 263 | Newborns | 5 | Asthma | OR 2.9 (1.2 to 7.1) | 7 |
| Kusel et al25 (respiratory viral infections study) | 2012 | Australia | 263 | Newborns | 10 | Asthma | RR 1.63 (0.77 to 3.45) | 7 |
| Midulla et al38 (recurrent wheezing study) | 2012 | Italy | 313 | ≤11 | 1–2 | Recurrent wheezing | OR 3.3 (1.0 to 11.1) | 6 |
| Midulla et al22 (recurrent wheezing study) | 2014 | Italy | 313 | ≤11 | 3–4 | Recurrent wheezing | OR 3.1 (1.0 to 9.4) | 7 |
| Lukkarinen et al20 (the Vinku Study) | 2013 | Finland | 111 | 3–35 | 7 | Recurrent wheezing | HR 3.54 (1.51 to 8.3) | 7 |
| van der Gugten et al14 (WHISTLER) | 2013 | The Netherlands | 140 | <1 | 4 | Wheezing | OR 1.4 (0.7 to 2.9) | 7 |
| Teeratakulpisarn et al21 (respiratory pathogens study) | 2014 | Thailand | 170 | 1–24 | 5–7 | Asthma | HR 1.34 (0.26 to 6.95) | 8 |
| Takeyama et al15 (paediatric patients cohort) | 2014 | Japan | 153 | ≤36 | 3–6 | Wheezing | RR 1.66 (1.145 to 2.4) | 7 |
| de Winter et al23 (healthy birth cohort study) | 2015 | The Netherlands | 290 | Newborns | 3 | Wheezing | OR 9.7 (3.1 to 33.5) | 8 |
COAST, Childhood Origins of ASThma; NOS, Newcastle-Ottawa Scale; RR, relative risk; WHISTLER, WHeezing illnesses Study LEidsche Rijn.