BFPE | Placebo | Difference in mean In FeNO, BFPE minus placebo† | Ratio mean In FeNO, BFPE vs placebo†‡ | p Value | |||
---|---|---|---|---|---|---|---|
Baseline (n=28) ppm | 4 weeks (n=28) ppm | Baseline (n=26) ppm | 4 weeks (n=25) ppm | ||||
Median | 68.0 | 73.5 | 63.0 | 67.0 | |||
IQR | 50.5 to 96.5 | 49.5 to 112.0 | 52.0 to 98.0 | 53.0 to 94.0 | |||
Ln§ mean | 4.27 | 4.28 | 4.24 | 4.22 | −0.002 | 1.0 | 0.98 |
(SD) | (0.44) | (0.47) | (0.38) | (0.47) | |||
(95% CI) | (−0.15 to 0.14) | (0.86 to 1.15) |
FeNO had a skewed distribution and the natural logarithm transformation (ln) was used in the analysis of comparison between treatments.
*IQR.
†Mixed linear model with baseline covariate.
‡Exponent of the difference in natural logarithms.
§Ln: natural logarithm.
BFPE, berryfruit polyphenolic extract; FeNO, fraction of exhaled nitric oxide.