Mean health-related quality of life during the 18-week intervention period and 18-week follow-up and the QALYs by cancer type and group allocation
| Intervention (mean (SD)) | Control (mean (SD)) | Mean difference (95% CI) | |
|---|---|---|---|
| n=87 | n=78 | ||
| Breast cancer | |||
| EQ-5D score | |||
| Baseline | 0.88 (0.13) | 0.87 (0.13) | 0.01 (−0.03 to 0.05) |
| 4 weeks | 0.85 (0.18) | 0.84 (0.17) | 0.01 (−0.04 to 0.06) |
| 8 weeks | 0.82 (0.19) | 0.80 (0.20) | 0.02 (−0.04 to 0.08) |
| 12 weeks | 0.78 (0.24) | 0.80 (0.20) | −0.01 (−0.08 to 0.06) |
| 16 weeks | 0.80 (0.21) | 0.82 (0.17) | −0.02 (−0.08 to 0.04) |
| 20 weeks | 0.84 (0.12) | 0.82 (0.17) | 0.01 (−0.03 to 0.06) |
| 24 weeks | 0.82 (0.16) | 0.77 (0.20) | 0.05 (−0.01 to 0.10) |
| 28 weeks | 0.79 (0.21) | 0.78 (0.18) | 0.01 (−0.06 to 0.07) |
| 32 weeks | 0.83 (0.17) | 0.80 (0.19) | 0.02 (−0.03 to 0.08) |
| 36 weeks | 0.82 (0.17) | 0.82 (0.19) | −0.004 (−0.06 to 0.05) |
| Average EQ-5D score during first 18 weeks | 0.83 (0.14) | 0.83 (0.12) | 0.001 (−0.04–0.04) |
| Average EQ-5D score during last 18 weeks | 0.82 (0.13) | 0.80 (0.14) | 0.02 (−0.03–0.06) |
| QALY total over 36 weeks | 0.566 (0.08) | 0.559 (0.08) | 0.007 (−0.02;0.03) |
| QALY total over 36 weeks (adjusted)* | 0.569 (0.03) | 0.560 (0.04) | 0.009 (−0.02;0.02) |
| n=14 | n=15 | ||
| Colon cancer | |||
| EQ-5D score | |||
| Baseline | 0.89 (0.11) | 0.82 (0.19) | 0.07 (−0.05 to 0.19) |
| 4 weeks | 0.84 (0.12) | 0.77 (0.17) | 0.07 (−0.04 to 0.18) |
| 8 weeks | 0.79 (0.16) | 0.80 (0.18) | −0.01 (−0.14 to 0.12) |
| 12 weeks | 0.79 (0.20) | 0.80 (0.18) | −0.01 (−0.16 to 0.14) |
| 16 weeks | 0.83 (0.11) | 0.82 (0.11) | 0.001 (−0.09 to 0.09) |
| 20 weeks | 0.90 (0.09) | 0.86 (0.10) | 0.04 (−0.03 to 0.12) |
| 24 weeks | 0.90 (0.01) | 0.83 (0.13) | 0.07 (−0.02 to 0.15) |
| 28 weeks | 0.89 (0.11) | 0.73 (0.21) | 0.16 (0.03 to 0.29) |
| 32 weeks | 0.90 (0.12) | 0.79 (0.15) | 0.12 (0.01 to 0.22) |
| 36 weeks | 0.89 (0.13) | 0.74 (0.21) | 0.14 (0.01 to 0.28) |
| Average EQ-5D score during first 18 weeks | 0.83 (0.10) | 0.80 (0.12) | 0.02 (−0.06 to 0.11) |
| Average EQ-5D score during last 18 weeks | 0.90 (0.07) | 0.79 (0.12) | 0.11 (0.03 to 0.18) |
| QALY total over 36 weeks | 0.593 (0.05) | 0.551 (0.07) | 0.042 (−0.01 to 0.09) |
| QALY total over 36 weeks (adjusted)* | 0.572 (0.03) | 0.546 (0.05) | 0.026 (−0.01 to 0.06) |
*Baseline adjusted QALYs were calculated over the 36 week observation period, following a regression analysis based method as proposed by Manca et al.21