Inclusion | Exclusion |
---|---|
18 years or older | Non-ambulatory |
Female | Severe debilitating disease (MS) |
Patients with stable MS≥3 months before screening | Urinary tract infection |
Neurogenic detrusor overactivity | Positive pregnancy test |
LUTS (urinary frequency, urgency) | Contraindication for MRI (ie, pacemaker, metal implants) |
Positive clinic UDS for neurogenic detrusor overactivity | Male |
Refractory to conservative and oral pharmacotherapy | History of incontinence surgery (ie, sling, MMK, Burch) |
History of LUT surgery (ie, urethral dilation) | |
Other neurological diseases (ie, spinal cord injury, myelomeningocele, Parkinson disease) |
LUT, lower urinary tract; LUTS, LUT symptoms; MS, multiple sclerosis; UDS, urodynamic study.