ORs for the risk of DIC in each study population*
| Study population A (overall population) | Study population B (laboratory data-available admissions only) | |||
|---|---|---|---|---|
| non-DM | T2DM | non-DM | T2DM | |
| All | ||||
| Number of admission | 306 100 | 260 091 | 259 633 | 53 793 |
| Number of DIC | 3287 (1.1%) | 4640 (1.8%) | 821 (0.3%) | 307 (0.6%) |
| Age, sex and admission year-adjusted OR | 1 | 1.60 (1.52 to 1.67) | 1 | 1.63 (1.43 to 1.87) |
| Further adjusting for underlying diseases | 1 | 1.39 (1.32 to 1.45) | 1 | 1.28 (1.11 to 1.47) |
| By underlying disease | ||||
| Sepsis | ||||
| Number of admission | 5 005 | 9211 | 3524 | 1611 |
| Number of DIC | 920 (18.4%) | 1 618 (17.6%) | 335 (9.5%) | 125 (7.8%) |
| Age, sex and admission year-adjusted OR | 1 | 0.97 (0.88 to 1.06) | 1 | 0.79 (0.64 to 0.99) |
| Further adjusting for underlying diseases | 1 | 0.98 (0.90 to 1.08) | 1 | 0.81 (0.65 to 1.01) |
| Non-septic severe infection | ||||
| Number of admission | 17 118 | 17 931 | 14 541 | 3681 |
| Number of DIC | 226 (1.3%) | 527 (2.9%) | 73 (0.5%) | 47 (1.3%) |
| Age, sex and admission year-adjusted OR | 1 | 2.05 (1.75 to 2.41) | 1 | 2.11 (1.44 to 3.07) |
| Further adjusting for underlying diseases | 1 | 1.67 (1.41 to 1.97) | 1 | 1.56 (1.05 to 2.30) |
| Solid tumour | ||||
| Number of admission | 111 908 | 82 305 | 96 398 | 19 127 |
| Number of DIC | 1 207 (1.1%) | 1 645 (2.0%) | 302 (0.3%) | 115 (0.6%) |
| Age, sex and admission year-adjusted OR | 1 | 1.89 (1.75 to 2.04) | 1 | 1.93 (1.55 to 2.40) |
| Further adjusting for underlying diseases | 1 | 1.59 (1.47 to 1.72) | 1 | 1.46 (1.16 to 1.83) |
| Acute leukaemia | ||||
| Number of admission | 1 809 | 1 604 | 1 148 | 386 |
| Number of DIC | 451 (24.9%) | 284 (17.7%) | 166 (14.5%) | 33 (8.5%) |
| Age, sex and admission year-adjusted OR | 1 | 0.73 (0.61 to 0.86) | 1 | 0.57 (0.38 to 0.84) |
| Further adjusting for underlying diseases | 1 | 0.70 (0.59 to 0.84) | 1 | 0.58 (0.39 to 0.87) |
Adjustment variables were age (continuous), sex (male or female), admission year (<2011, 2011, 2012, 2013 or 2014) and underlying diseases (sepsis, non-septic severe infection, solid tumour and acute leukaemia; yes or no, for each).
*DIC was defined based on the physician's diagnosis of DIC only in study population A, and the physician's diagnosis of DIC with supporting laboratory data in study population B.
DIC, disseminated intravascular coagulation; T2DM, type 2 diabetes mellitus.