Table 1

Characteristics of patients with congenital cytomegalovirus (cCMV) infection

	Screening for CMV		Re-examination of CMV		First MRI examination		Second MRI examination		AABR
Pt no	Age (days)	Copies/mL	Age (weeks)	Copies/mL	Age (weeks)	Findings	Age (months)	Findings	Right	Left	Outcome*
1†	1	1.9×10⁸	5	1.9×10⁸	6	WMA, periventricular cysts	27	WMA, ventriculomegaly	R (−90 dB)‡	P	SNHL, PDD, speech delay
2†	4	8.0×10⁶	2	7.2×10⁷	12	WMA	18	WMA	R (−100 dB)	R (−70 dB)	SNHL, PDD, speech delay, calcification§
3†	0	3.2×10⁸	24	2.5×10⁶	78	WMA, ventriculomegaly, hippocampal dysplasia	Declined		R (−80 dB)	R (no response)	SNHL, PDD, speech delay
4†	4	4.8×10⁶	3	7.1×10⁷	4	WMA	18	WMA	R (−100 dB)	P	SNHL, PDD, speech delay
5†	1	1.5×10⁷	32	2.1×10⁷	6	WMA	9	WMA, cerebral parenchymal atrophy	ND	ND	Late-onset hearing loss
6	1	4.1×10⁶	10	1.8×10⁶	12	Polymicrogyria, ventriculomegaly, WMA	18	Polymicrogyria, WMA, ventriculomegaly, periventricular cysts	P	P	Left hemiparesis, PDD
7	2	1.0×10⁷	5	1.8×10⁸	8	WMA	18	WMA	P	P	Microcephaly, speech delay
8	4	5.2×10⁵	9	2.0×10⁶	7	WMA, vestibulo-semicircular canal dysplasia	Not yet done¶		P	P
9	1	8.0×10⁶	41	2.5×10⁷	40	WMA, infarct	18	WMA	P	P
10	4	2.1×10⁶	6	8.6×10⁷	7	WMA, coagulation, necrosis around posterior horn of both lateral ventricles	18	WMA	P	P
11	1	2.5×10⁶	5	5.3×10⁷	5	WMA	18	WMA, ventriculomegaly	P	P
12	1	3.1×10⁷	10	3.1×10⁷	12	WMA	18	WMA	P	P
13	2	2.0×10⁵	6	5.0×10⁴	11	WMA	18	WMA	P	P
14	4	3.3×10⁸	6	4.9×10⁷	6	WMA	18	WMA	P	P
15	4	5.4×10⁸	8	4.3×10⁸	6	WMA	18	WMA	P	P
16	4	1.3×10⁵	8	2.2×10⁶	11	WMA	18	WMA	P	P
17	4	1.0×10⁷	5	3.8×10⁶	7	WMA	18	WMA	P	P
18	3	1.3×10⁷	4	2.3×10⁶	12	WMA	19	WMA	P	P
19	4	5.7×10⁶	3	4.5×10⁶	3	WMA	9	WMA	P	P
20	4	2.3×10⁵	No urine collection		8	WMA	12	WMA	P	P
21	1	4.8×10⁷	5	9.4×10⁵	8	WMA	11	WMA	P	P
22	4	4.8×10⁷	5	1.1×10⁷	6	WMA	17	WMA	ND	ND
23	4	1.4×10⁵	10	1.4×10⁷	12	WMA	18	WMA	P	P
24	4	7.3×10⁴	5	7.6×10⁴	5	WMA	17	WMA	P	P
25	4	9.2×10⁴	6	1.1×10⁶	4	WMA	17	WMA	P	P
26	4	7.9×10⁵	8	1.5×10⁷	9	WMA	18	WMA	P	P
27	2	3.5×10⁴	6	3.5×10⁵	10	WMA	18	Normal	P	P
28	4	3.6×10⁵	8	3.4×10⁶	11	WMA	17	Normal	P	P
29	1	4.0×10⁷	9	1.8×10⁶	13	WMA	17	Normal	P	P
30	4	9.6×10⁴	5	1.1×10⁷	8	WMA	19	Normal	P	P
31	1	1.1×10⁶	9	2.1×10⁵	11	WMA	18	Normal	ND	ND
32	1	1.6×10⁸	4	6.9×10⁷	5	WMA	Declined		P	P
33	4	1.9×10⁵	9	6.6×10⁵	14	WMA	Declined		P	P
34	4	5.1×10⁶	15	2.9×10⁵	7	WMA	Not yet done		P	P
35	4	3.7×10⁵	8	3.4×10⁵	8	WMA	Declined		P	P
36	4	1.1×10⁴	6	4.8×10⁵	8	WMA	Not yet done		P	P
37	1	3.9×10⁴	6	1.3×10⁵	5	WMA	Not yet done		ND	ND
38	1	1.5×10⁷	No urine collection		7	WMA	Not yet done		P	P
39	4	6.9×10⁷	15	9.8×10⁶	14	Normal	20	WMA	P	P
40	1	1.1×10⁹	16	2.0×10⁷	18	Normal	18	WMA	P	P
41	1	3.5×10⁷	10	6.2×10⁶	13	Normal	17	WMA	P	P
42	4	6.7×10⁵	8	6.2×10⁵	10	Normal	24	WMA	P	P
43	4	3.6×10⁵	9	4.7×10⁶	11	Normal	22	WMA	P	P	Cavum vergae
44	2	1.4×10⁷	8	4.4×10⁵	9	Normal	18	WMA	ND	ND
45	4	6.1×10⁴	8	6.1×10⁴	7	Normal	16	Normal	P	P
46	4	3.8×10⁴	11	2.2×10⁶	16	Normal	18	Normal	P	P
47	4	1.2×10⁶	12	1.6×10⁷	12	Normal	17	Normal	P	P
48	1	4.5×10³	4	3.1×10⁵	4	Normal	Declined		P	P
49	1	6.4×10⁶	14	4.1×10⁵	15	Normal	Declined		P	P
50	4	7.4×10⁵	13	2.2×10⁶	28	Normal	Declined		P	P
51	4	6.1×10⁴	3	1.2×10⁵	5	Normal	Declined		P	P
52	4	1.1×10⁶	13	6.0×10⁶	12	Normal	Not yet done		P	P
53	4	9.3×10⁵	7	3.9×10⁶	8	Normal	Not yet done		P	P
54	1	1.1×10⁴	Not examined**		Not examined		Not examined		P	P
55	1	3.1×10⁶	Not examined		Not examined		Not examined		P	P
56	3	2.4×10⁶	Not examined		Not examined		Not examined		P	P
57	4	7.7×10⁶	Not examined		Not examined		Not examined		P	P
58	4	2.4×10³	Not examined		Not examined		Not examined		P	P
59	1	1.0×10⁴	Not examined		Not examined		Not examined		ND	ND
60	2	1.1×10⁸	Not examined		Not examined		Not examined		ND	ND

Microcephaly was noted in one newborn with modified HC z score of −2.95.
*No data means the patient had shown no apparent clinical manifestations until documentation of this paper.
†The oral antiviral drug valganciclovir was administered to patients 1–5 with SNHL for 5–6 months. Patient 5 presented with late-onset hearing loss and was then treated with valganciclovir.
‡Figures in parentheses indicate hearing loss measured in decibel (dB).
§Calcification was confirmed with CT scan.
¶Not yet done means that the second MRI examination is scheduled but had not yet been done until documentation of this paper.
**Not examined means no visit or examinations.
AABR, automatic auditory brainstem response; HC, nead circumference; nt, not tested; P, pass; PDD, psychomotor developmental delays; Pt no, patient number; R, refer; SNHL, sensorineural hearing loss; WMA, white matter abnormality.