HRs of sepsis according to ALS status stratified by sex, age and CCI score
| ALS group | |||||
|---|---|---|---|---|---|
| HR (95% CI) | |||||
| Variables | Non-ALS group | Crude | Model 1 | Model 2 | Model 3 |
| Sex | |||||
| Women | ref | 7.18 (4.72 to 10.9)*** | 8.45 (5.51 to 12.9)*** | 4.25 (2.53 to 7.14)*** | 4.31 (2.56 to 7.24)*** |
| Men | ref | 6.81 (5.15 to 9.00)*** | 8.00 (6.02 to 10.6)*** | 3.34 (2.40 to 4.63)*** | 3.42 (2.46 to 4.75)*** |
| Age, years | |||||
| 20–44 | ref | 30.7 (8.90 to 106)*** | 30.8 (8.93 to 106)*** | 8.27 (1.89 to 36.2)** | 7.80 (1.72 to 35.3)** |
| 45–69 | ref | 9.90 (7.29 to 13.5)*** | 10.0 (7.36 to 13.6)*** | 3.77 (2.60 to 5.48)*** | 3.77 (2.59 to 5.48)*** |
| ≥70 | ref | 3.43 (2.18 to 5.39)*** | 3.79 (2.40 to 5.99)*** | 2.11 (1.30 to 3.45)** | 2.35 (1.43 to 3.84)*** |
| CCI score | |||||
| 0 | ref | 12.6 (8.98 to 17.6)*** | 14.3 (10.2 to 20.1)*** | 4.22 (2.79 to 6.39)*** | 4.53 (2.99 to 6.86)*** |
| 1–2 | ref | 4.13 (2.78 to 6.14)*** | 4.63 (3.10 to 6.92)*** | 2.57 (1.64 to 4.04)*** | 2.58 (1.64 to 4.06)*** |
| ≥3 | ref | 3.99 (1.71 to 9.33)** | 4.09 (1.73 to 9.67)** | 3.56 (1.44 to 8.80)** | 3.71 (1.47 to 9.34)** |
Model 1 mutually adjusting for sex, age (continuous), CCI score (continuous) and medications therapy.
Model 2 mutually adjusting for sex, age (continuous), CCI score (continuous), ICU and ventilator use.
Model 3 mutually adjusting for sex, age (continuous), CCI score (continuous), medications therapy, ICU and ventilator use.
**p<0.01, ***p<0.001.
ALS, amyotrophic lateral sclerosis; CCI, Charlson comorbidity index.