Overview of inclusion and exclusion criteria
| Inclusion criteria | |
| Patients with TLE | Control patients |
| Mentally competent patients between 18 and 60 years of age. | Mentally competent patients between 18 and 60 years of age. |
| Patients undergoing resective surgery as treatment of drug-resistant TLE with an epileptic focus, ie, located in a non-eloquent area. | Patients undergoing an elective craniotomy for intracranial tumour resection or neurovascular surgery, or undergoing burr hole surgery for tumour biopsy in a non-eloquent area. |
| Exclusion criteria | |
| Applicable to all patients | |
| Patients who are pregnant, who have been diagnosed for diabetes mellitus, hyperlipidaemia, stroke, or other cardiovascular diseases, or use of cardiovascular medication. | |
| Patients who, based on brain MRI, show non-symptomatic signs of cerebral small vessel disease. | |
| Applicable to control patients only | |
| Patients in whom no ‘normal’, ‘non-compressed’ and/or ‘non-edematous’ cerebral cortex can be assessed intraoperatively. | |
| Patients with a history of seizures. | |
TLE, temporal lobe epilepsy.