Characteristics | Control (n=45) | rhTM* (n=47) | OR (95% CI) | p Value |
---|---|---|---|---|
Sepsis-induced hypotension,† n (%) | 26 (57.8) | 17 (36.1) | 0.42 (0.96 to 6.09) | 0.059* |
Vasopressor, n (%) | 27 (60.0) | 16 (34.0) | 0.35 (0.13 to 0.87) | 0.021* |
Norepinephrine, n (%) | 23 (51.1) | 13 (28.9) | ||
Dopamine, n (%) | 1 (2.2) | 1 (2.2) | ||
Dobutamine, n (%) | 1 (2.2) | 1 (2.2) | ||
Epinephrine, n (%) | 2 (4.45) | 1 (2.2) | ||
Bacteraemia (blood culture positive) | 22 (48.9) | 29 (61.7) | 1.67 (0.68 to 4.19) | 0.294* |
Site of infection, n (%) | 0.795‡ | |||
Lung | 17 (37.8) | 19 (40.4) | ||
Urinary tract/kidney | 18 (40.0) | 13 (27.7) | ||
Gastrointestinal | 8 (8.8) | 5 (10.6) | ||
Skin/soft tissue | 3 (6.7) | 4 (8.5) | ||
Others | 2 (44.4) | 3 (6.4) | ||
Responsible organism | ||||
Gram-negative rod | 27 (60.0) | 32 (68.0) | 1.42 (0.56 to 3.66) | 0.515* |
Gram-positive coccus | 18 (40.0) | 15 (31.9) | ||
Antibiotic | ||||
Carbapenem | 26 (57.8) | 31 (66.0) | 0.530‡ | |
Cephalosporin | 18 (40.0) | 14 (29.8) | ||
Other | 1 (2.2) | 2 (4.3) | ||
Renal replacement therapy, n | 6 (13.3) | 5 (10.6) | 0.78 (0.17 to 3.33) | 0.756* |
Duration, day | 9.0 (8.3, 13.5)§ | 3.0 (2.0, 6.0)§ | NA | 0.099¶ |
Mechanical ventilation, n (%) | 26 (57.8) | 21 (44.7) | 0.59 (0.24 to 1.46) | 0.220* |
*Fisher's exact test was performed.
†Sepsis-induced hypotension was defined as follows; despite adequate fluid resuscitation, vasopressors required to maintain mean arterial pressure ≥65 mm Hg.
‡χ2 Test was performed.
§The data were shown median and 25th and 75th centiles (25, 75 perventile).
¶Mann-Whitney test was performed.
NA, none available; rhTM, recombinant human thrombomodulin.