Risk of skeletal fluorosis associated with VDR-FokI polymorphic genotypes in study participants overall and stratified by ethnicity
| Genotype | Case (n (%)) | Control n (%) | Crude OR (95% CI) | Adjusted OR (95% CI)* |
|---|---|---|---|---|
| All participants | ||||
| CC | 143 (42.6) | 329 (34.7) | 1.0 (ref) | 1.0 (ref) |
| CT+TT | 193 (57.4) | 619 (65.3) | 0.717 (0.556 to 0.925) | 0.761 (0.580 to 0.997) |
| Tibetan | ||||
| CC | 44 (35.8) | 62 (33.5) | 1.0 (ref) | 1.0 (ref) |
| CT+TT | 79 (64.2) | 123 (66.5) | 0.905 (0.561 to 1.461) | 0.947 (0.562 to 1.598) |
| Kazakh | ||||
| CC | 50 (51.0) | 85 (44.3) | 1.0 (ref) | 1.0 (ref) |
| CT+TT | 48 (49.0) | 107 (55.7) | 0.763 (0.468 to 1.242) | 0.729 (0.439 to 1.210) |
| Mongolian | ||||
| CC | 31 (53.4) | 70 (34.5) | 1.0 (ref) | 1.0 (ref) |
| CT+TT | 27 (46.6) | 133 (65.5) | 0.458 (0.254 to 0.828) | 0.525 (0.278 to 0.991) |
| Han | ||||
| CC | 18 (31.6) | 112 (30.4) | 1.0 (ref) | 1.0 (ref) |
| CT+TT | 39 (68.4) | 256 (69.6) | 0.948 (0.520 to 1.729) | 0.945 (0.503 to 1.774) |
Bold indicates p<0.05.
*Adjusted for age, sex, ITF and UF.
ITF, daily intake of tea fluoride; UF, urine fluoride; VDR, vitamin D receptor.