Univariate and bivariate logistic regression models of risk factors for symptomatic cardiotoxicity
| β coefficient (95% CI) | OR (95% CI) | p Value | β coefficient (95% CI) | OR (95% CI) | p Value | |
|---|---|---|---|---|---|---|
| Variable | Univariate | Bivariate: adjusted for age | ||||
| All patients (N=452) (events=22) | ||||||
| Age* | 0.01 (−0.03 to 0.04) | 1.01 (0.97 to 1.05) | 0.789 | – | – | – |
| Hypercholesterolaemia† | 1.42 (0.43 to 2.40) | 4.12 (1.54 to 11.00) | 0.005 | 1.42 (0.38 to 2.46) | 4.14 (1.46 to 11.75) | 0.008 |
| Hypertension† | 0.58 (−0.29 to 1.46) | 1.79 (0.75 to 4.31) | 0.192 | 0.60 (−0.33 to 1.52) | 1.82 (0.72 to 4.57) | 0.206 |
| Diabetes† | −0.07 (−2.12 to 1.99) | 0.94 (0.12 to 7.32) | 0.949 | −0.11 (−2.17 to 1.96) | 0.90 (0.11 to 7.13) | 0.921 |
| Smoking† | ||||||
| Current smoker | 1.30 (0.17 to 2.42) | 3.66 (1.19 to 11.21) | 0.023 | 1.30 (0.18 to 2.42) | 3.66 (1.19 to 11.22) | 0.023 |
| Former smoker | 0.92 (−0.42 to 2.27) | 2.52 (0.66 to 9.66) | 0.179 | 0.92 (−0.43 to 2.27) | 2.51 (0.65 to 9.67) | 0.181 |
| BMI* | −0.05 (−0.16 to 0.06) | 0.95 (0.85 to 1.06) | 0.380 | −0.05 (−0.16 to 0.07) | 0.96 (0.85 to 1.07) | 0.413 |
| Previous irradiation of left breast† | −0.14 (−1.05 to 0.78) | 0.87 (0.35 to 2.18) | 0.763 | −0.13 (−1.05 to 0.80) | 0.88 (0.35 to 2.22) | 0.785 |
| “Cardiac comorbidity”† | 1.63 (0.67 to 2.59) | 5.12 (1.96 to 13.39) | 0.001 | 1.70 (0.70 to 2.69) | 5.47 (2.02 to 14.80) | 0.001 |
| Anemia† | −0.86 (−2.12 to 0.39) | 0.42 (0.12 to 1.47) | 0.176 | −0.86 (−2.12 to 0.39) | 0.42 (0.12 to 1.47) | 0.176 |
| eGFR* | −0.01 (−0.03 to 0.02) | 0.99 (0.97 to 1.02) | 0.487 | −0.01 (−0.03 to 0.02) | 0.99 (0.97 to 1.02) | 0.638 |
| Previous anthracyclines† | −0.58 (−1.43 to 0.29) | 0.56 (0.24 to 1.34) | 0.194 | −0.73 (−1.77 to 0.31) | 0.48 (0.17 to 1.36) | 0.171 |
| Previous or concurrent trastuzumab† | 0.08 (−1.17 to 1.34) | 1.08 (0.31 to 3.80) | 0.903 | 0.11 (−1.17 to 1.41) | 1.12 (0.31 to 4.09) | 0.864 |
| Dose of capecitabine* | −0.01 (−0.03 to 0.02) | 1.00 (0.97 to 1.02) | 0.666 | −0.01 (−0.03 to 0.02) | 1.00 (0.97 to 1.02) | 0.682 |
| Previous thoracic irradiation† | 0.08 (−1.08 to 1.24) | 1.08 (0.34 to 3.44) | 0.892 | 0.12 (−1.05 to 1.28) | 1.12 (0.35 to 3.60) | 0.847 |
| Patients with no history of heart disease (n=399) (events=15) | ||||||
| Age* | 0.001 (−0.04 to 0.05) | 1.00 (0.96 to 1.05) | 0.949 | – | – | – |
| Hypercholesterolaemia† | 1.32 (0.01 to 2.55) | 3.75 (1.10 to 12.81) | 0.035 | 1.34 (0.04 to 2.63) | 3.81 (1.04 to 13.94) | 0.043 |
| Hypertension† | 0.05 (−1.11 to 1.22) | 1.05 (0.33 to 3.38) | 0.929 | 0.04 (−1.17 to 1.25) | 1.04 (0.31 to 3.51) | 0.947 |
| Diabetes† | 0.48 (−1.61 to 2.57) | 1.62 (0.20 to 13.10) | 0.651 | 0.48 (−1.63 to 2.58) | 1.61 (0.20 to 13.26) | 0.658 |
| Smoking† | ||||||
| Current smoker | 1.64 (0.26 to 3.01) | 5.13 (1.30 to 20.33) | 0.020 | 1.63 (0.25 to 3.00) | 5.09 (1.28 to 20.18) | 0.021 |
| Former smoker | 0.18 (−2.10 to 2.46) | 1.20 (0.12 to 11.76) | 0.876 | 0.19 (−2.10 to 2.47) | 1.21 (0.12 to 11.85) | 0.872 |
| BMI* | −0.04 (−0.18 to 0.09) | 0.96 (0.84 to 1.09) | 0.530 | −0.04 (−0.17 to 0.10) | 0.96 (0.84 to 1.10) | 0.578 |
| Previous irradiation of left breast† | −0.41 (−1.56 to 0.76) | 0.67 (0.21 to 2.13) | 0.495 | −0.41 (−1.56 to 0.77) | 0.67 (0.21 to 2.15) | 0.497 |
| Anemia† | −1.62 (−3.51 to 0.43) | 0.20 (0.03 to 1.54) | 0.121 | −1.62 (−3.51 to 0.43) | 0.20 (0.03 to 1.54) | 0.121 |
| eGFR* | 0.00 (−0.03 to 0.03) | 1.00 (0.97 to 1.03) | 0.876 | 0.01 (−0.03 to 0.05) | 1.01 (0.97 to 1.05) | 0.668 |
| Previous anthracyclines† | 0.67 (−0.39 to 1.72) | 1.96 (0.68 to 5.60) | 0.212 | 0.92 (−0.33 to 2.18) | 2.52 (0.72 to 8.86) | 0.150 |
| Previous or concurrent trastuzumab† | 0.42 (−0.87 to 1.72) | 1.53 (0.42 to 5.60) | 0.525 | 0.48 (−0.87 to 1.83) | 1.62 (0.42 to 6.26) | 0.484 |
| Dose of capecitabine* | −0.01 (−0.04 to 0.02) | 0.99 (0.96 to 1.02) | 0.573 | −0.01 (−0.04 to 0.02) | 0.99 (0.96 to 1.02) | 0.579 |
| Previous thoracic irradiation† | 0.35 (−1.02 to 1.72) | 1.42 (0.36 to 5.59) | 0.621 | 0.40 (−0.99 to 1.79) | 1.48 (0.37 to 5.96) | 0.577 |
Bold p values indicate a significant difference (p<0.05).
*Scale variable.
†Categorical variable.
‘Cardiac comorbidity’, all types of heart disease; BMI, body mass index; eGFR, estimated glomerular filtration rate.