Reporting of (a) missing data and (b) sensitivity analyses
| n (%) | |
|---|---|
| (a) Imputation performed | |
| Yes | 56 (33) |
| Worst-case scenario | 19 (34) |
| Multiple imputation | 11 (20) |
| Last observation carried forward | 8 (14) |
| Complete case analysis | 6 (11) |
| Best-case scenario | 2 (4) |
| Last observation carried forward and worst-case scenario | 2 (4) |
| Best-case/worst-case scenario | 3 (5) |
| Mean imputation | 1 (2) |
| Complete case analysis, multiple imputation using propensity scores and multiple imputation using regression modelling | 1 (2) |
| Other and worst-case scenario | 1 (2) |
| Other | 1 (2) |
| No | 12 (7) |
| Not reported | 99 (59) |
| Unclear | 1 (1) |
| Including NEJM protocols (N=61) | |
| Yes | 22 (36) |
| No | 7 (11) |
| Not reported | 31 (51) |
| Unclear | 1 (2) |
| (b) Sensitivity analyses performed | |
| Yes | 64 (38) |
| Patient population | 13 (20) |
| Competing risks | 2 (3) |
| Statistical modelling | 2 (3) |
| Adjusted for baseline variables | 1 (2) |
| Excluded protocol violations | 1 (2) |
| On-treatment | 1 (2) |
| Patient population/other | 1 (2) |
| Unclear | 2 (3) |
| Other | 15 (23) |
| Missing data | 27 (42) |
| Best-case/worst-case scenario | 5 |
| Complete case analysis | 3 |
| Imputation of missing values | 3 |
| Multiple imputation | 3 |
| Worst-case scenario | 3 |
| Baseline observation carried forward | 1 |
| Baseline observation carried forward and complete case analysis | 1 |
| Complete case analysis, multiple imputation using propensity scores and multiple imputation using regression modelling | 1 |
| Complete case analysis and missing not at random | 1 |
| Complete case analysis and best-case scenario | 1 |
| Different methods | 1 |
| Last observation carried forward | 1 |
| Modelling | 1 |
| Observed failure | 1 |
| Worst-case scenario and last observation carried forward | 1 |
| No | 103 (61) |
| Unclear | 1 (1) |
| Including NEJM protocols | |
| Yes | 38 (62) |
| No | 23 (38) |