Table 1

Selected patient characteristics and end points

LOVSEXPRESSALVEOLIALL
CharacteristicsHigher PEEP N=475Lower PEEP N=508Higher PEEP N=385Lower PEEP N=382Higher PEEP N=276Lower PEEP N=273Higher PEEP N=1136Lower PEEP N=1163
Age54.5 (16.5)56.9 (16.5)60.1 (15.7)59.7 (15.1)53.7 (17.1)48.5 (16.9)56.2 (16.6)55.9 (16.7)
Women, N (%)193 (40.6)201 (39.5)125 (32.9)126 (33.2)119 (43.1)128 (46.9)437 (38.5)455 (39.1)
BMI27.5 (6.5, (23.1–30.4))27.2 (6.8, (23.0–30.1))26.3 (5.8, (22.5–29.0))26.3 (6.1, (22.4–29.2))27.8 (6.8, (22.7–30.7))27.2 (7.0, (22.1–30.2))27.2 (6.4, (22.9–30.1))26.9 (6.6, (22.6–30.0))
Missing values, N (%)72 (15.2)85 (16.7)17 (4.4)19 (5.0)23 (8.3)21 (7.7)112 (9.6)125 (10.7)
PaO2/FIO2145.1 (48.3, (106.7–177.8))144.7 (49.1, (105.5–181.3))144 (57.6, (101.7–180.0))142.7 (56.9, (94.3–180.0))151 (67.3, (102.0–191.4))163 (76.2, (105.0–207.5))146 (56.6, (103.3–180.0))148.4 (59.5, (101.7–186.0))
Missing values, N (%)1 (0.2)2 (0.4)0 (0)0 (0)0 (0)0 (0)1 (0.1)2 (0.2)
Oxygenation index14.4 (8.3, (8.7–17.2))14.4 (8.1, (8.5–18.0))13.1 (7.6, (7.9–16.0))13.0 (8.2, (7.4–16.1))13.1 (8.5, (7.4–16.7))12.1 (8.0, (6.8–15))13.6 (8.1, (8.2–16.8))13.4 (8.2, (7.8–17.0))
Missing values, N (%)51 (10.7)63 (12.4)80 (20.8)73 (19.3)16 (5.8)18 (6.6)147 (12.9)154 (13.2)
Estimated RC33.4 (16.9, (21.9–35.8))35.8 (21.6, (23.2–36.7))33.0 (12.3, (24.3–40.0))33.0 (11.6, (24.0–40.0))36.0 (20.7, (23.5–41.7))31.2 (12.8, (22.2–37.5))33.9 (16.6, (23.1–39.0))33.8 (17.1, (23.3–38.5))
Missing values, N (%)148 (31.2)170 (21.1)12 (3.1)12 (3.1)34 (12.3)35 (12.8)194 (17.1)217 (18.7)
Probability of death*52.9 (23.5)55.7 (23.2)45.8 (26.6)44.5 (27.0)49.0 (21.8)47.1 (21.1)49.6 (24.4)50.0 (24.6)
Missing values, N (%)0 (0)0 (0)0 (0)0 (0)3 (1.1)3 (1.1)3 (0.3)3 (0.3)
Severe sepsis, N (%)214 (45.1)248 (48.7)285 (75.0)268 (70.7)96 (34.8)112 (41.0)595 (52.4)628 (54.0)
Deaths in hospital, N (%)162 (34.1)192 (37.7)136 (35.8)149 (39.3)76 (27.5)68 (24.9)374 (32.9)409 (35.2)
Pts achieved UAB, N (%)309 (65.1)315 (62.0)237 (61.6)210 (55.7)195 (70.7)199 (72.9)741 (65.2)724 (62.2)
Barotrauma, N (%)45 (9.5)38 (7.5)26 (6.8)22 (5.8)16 (5.8)15 (5.5)87 (7.7)75 (6.4)
  • Values are means (SD, (IQR)) unless specified otherwise. Summary statistics of the characteristics are based on the imputed data set.

  • *According to APACHE II and SAPS scores.

  • BMI, body mass index; RC, respiratory compliance (tidal volume in mL/inspiratory plateau pressure−PEEP in mm Hg); PEEP, positive end-expiratory pressure; PaO2, arterial partial oxygen pressure (mm Hg); FiO2, fraction of inspired oxygen; Pts, patients; UAB, unassisted breathing.