Table 3

Multisource cholestatic liver injury algorithm—results of case status assignment

CPRD (Read) diagnostic codeHES diagnostic (ICD-10) code (plus HES procedural code or ONS mortality code, where considered)CPRD liver test resultMultisource algorithm case status(N=16 040) n (%)
Group 1|2|3*Not consideredCholestaticDefinite4032 (25)
Group 1|2|3ONS (mortality): group 1Not consideredDefinite0 (0)
Group 1|2|3HES biopsy/scan+group 1Not consideredDefinite1 (0)
Total definite4033 (25)
Group 1Group 1None†Very likely0 (0)
Total very likely0 (0)
Group 1Group 2 or no HES record‡NoneProbable0 (0)
Group 2|3Group 1NoneProbable4 (0)
Total probable4 (0)
Group 1Group 1|2Not cholestatic§Possible1 (0)
Group 1HES no codes of interest¶NonePossible25 (0)
Group 2Group 1Not cholestaticPossible4 (0)
Group 2Group 2NonePossible947 (6)
Total possible977 (6)
Group 1No HES record|
HES no codes of interest		Not cholestaticUnlikely22 (0)
Group 2No HES record|
HES no codes of interest		NoneUnlikely3468 (22)
Group 3Group 1Not cholestaticUnlikely2 (0)
Total unlikely3492 (22)
Group 2Group 2|no HES record|
HES no codes of interest		Not cholestaticNon-case2869 (18)
Group 3Group 2None|not cholestaticNon-case173 (1)
Group 3No HES recordNone|not cholestaticNon-case340 (2)
Group 3HES no codes of interestNone|not cholestaticNon-case4152 (26)
Total non-case7534 (47)

  • *Group 1=highest evidence for cholestatic liver injury and group 3=lowest evidence.

  • †No liver test result recorded within 90 days of index diagnosis.

  • ‡No HES record indicates that person did not attend hospital <1 year either side of index diagnosis.

  • §Liver test result was recorded <90 days from index diagnosis, but results indicate either no injury or pure hepatic injury.

  • ¶Person attended hospital <1 year from index diagnosis but no liver diagnoses of interest.

  • CPRD, Clinical Practice Research Datalink; HES, Hospital Episodes Statistics.