Results of logistic regressions of the probability of favourable and provisional opinions, treating each application as the unit of analysis
| Favourable opinion | Provisional opinion | |||||
|---|---|---|---|---|---|---|
| Variable | OR | 95% CI | p Value | OR | 95% CI | p Value |
| Year (2013 vs 2012) | 0.73 | 0.56 to 0.96 | 0.025 | 1.32 | 1.02 to 1.71 | 0.034 |
| EO vs comparator | 0.80 | 0.35 to 1.84 | 0.59 | 1.10 | 0.50 to 2.42 | 0.82 |
| Year×(EO vs comparator) | 1.35 | 0.80 to 2.29 | 0.26 | 0.77 | 0.48 to 1.27 | 0.31 |
| CTIMP status (no vs yes) | 2.34 | 1.62 to 3.37 | <0.001 | 0.38 | 0.26 to 0.54 | <0.001 |
| % interventional (per percentage point) | 1.00 | 0.99 to 1.01 | 0.90 | 1.00 | 0.99 to 1.01 | 0.50 |
| Workload (studies per meeting) | 0.88 | 0.70 to 1.09 | 0.24 | 1.01 | 0.82 to 1.24 | 0.97 |
CTIMP, Clinical Trials of Investigational Medicinal Products; EO, ethics officer.