Table 4

Cost-consequence matrix

Cost and outcomes	Usual care	N	Intervention	N	Difference (95% CI)
Available data on costs (£)
Mean cost of intervention	0	316	129	325	–
Mean cost of NHS resources, excluding intervention costs	361	283	362	285	1 (−72 to 76)*
Mean cost of NHS resources, including intervention costs	361	283	494	283	132 (57 to 212)*
Out-of-pocket expenses	64	298	79	299	15 (−20 to 50)*
Private healthcare	110	298	59	299	−50 (−141 to 1)*
Mean societal value per patient of lost production	76	298	52	299	−24 (−133 to 54)*
Consequences†
QRISK2 response to treatment (proportion of responders)	43%	291	50%	295	Adjusted OR 1.3 (1.0 to 1.9)
EQ-5D-5L at 12 months, unadjusted for baseline‡	0.776	297	0.812	295	0.037 (0.007 to 0.070)*
QALYs, adjusted for baseline‡	0.788	279	0.799	275	0.01 (−0.014 to 0.040)*

*CI calculated as accelerated and bias corrected interval from 1000 bootstrap replicates to account for skewed distributions.
†All consequences measured at 12 months, or over a period of 12 months.
‡Based on available data.
NHS, National Health Service; QALYs, quality-adjusted life years.