Description of the MEDALZ cohort (N=70 719) at baseline (date of AD diagnosis).
| Characteristic | n (%) |
|---|---|
| Sex | |
| Men | 24 602 (34.8) |
| Women | 46 117 (65.2) |
| Year of AD diagnosis | |
| 2005 | 8547 (12.1) |
| 2006 | 8803 (12.5) |
| 2007 | 9442 (13.4) |
| 2008 | 10 327 (14.6) |
| 2009 | 10 500 (14.9) |
| 2010 | 10 878 (15.4) |
| 2011 | 12 222 (17.3) |
| Highest occupational social class during 1972-AD diagnosis | |
| Managerial/professional | 14 680 (20.8) |
| Office worker | 5974 (8.5) |
| Farming/forestry | 13 443 (19.0) |
| Sales/industry/cleaning | 30 150 (42.6) |
| Unknown | 5932 (8.4) |
| Did not respond | 540 (0.8) |
| Highest socioeconomic position recorded for study participants in their middle age (age 45–55 years) | |
| Entrepreneurs and higher clerical workers | 24 164 (34.2) |
| Lower clerical workers and employees | 40 895 (57.8) |
| Unemployed, conscripts, retired and students | 4830 (6.8) |
| Unknown/missing | 829 (1.2) |
| History of comorbidities | |
| Cardiovascular disease (special reimbursement register) | 35 921 (50.8) |
| Hospitalisation due to ischaemic heart disease (ICD-10 code I20-I25) | 18 468 (26.1) |
| Hospitalisation due to stroke (ICD-10 code I60-I64) | 6828 (9.7) |
| Diabetes (special reimbursement register) | 9461 (13.4) |
| Hospitalisation due to diabetes (ICD-10 code E10-E14) | 7384 (10.4) |
| Asthma/chronic obstructive pulmonary disease (special reimbursement register) | 6199 (8.8) |
| Hospitalisation due to asthma/chronic obstructive pulmonary disease (ICD-10 code J44-J46) | 5267 (7.5) |
| Hospitalisation due to hip fracture (ICD10-code S720-S721) | 3714 (5.3) |
| Hospitalisation due to any mental or behavioural disorder (ICD-10 code F*) | 16 668 (23.6) |
| Disorders due to psychoactive substance use (ICD-10 code F1*) | 1832 (2.6) |
| Schizophrenia, schizotypal and delusional disorders (ICD-10 code F2*) | 1882 (2.7) |
| Depression (ICD-10 code F32-F34, F38-F39) | 3760 (5.3) |
| Mania and bipolar disorder (ICD-10 code F30-F31) | 504 (0.8) |
| Neurotic, stress-related and somatoform disorders (ICD-10 code F4*) | 1756 (2.5) |
| Disorders of adult personality and behaviour (ICD-10code F6*) | 270 (0.4) |
| History of medication use | |
| Any antipsychotic (ATC-code N05A) | 12 009 (17.0) |
| Any antiepileptic medication (ATC-code N03A) | 7176 (10.1) |
| Any opioids (ATC-code N02A) | 17 381 (24.6) |
| Any antidepressants (ATC-code N06A) | 22 984 (32.5) |
| Benzodiazepines (ATC codes N05BA, N05CD, N05CF) | 31 424 (44.4) |
| Any diabetes drug (ATC code A10) | 13 433 (19.0) |
| Any CVD drug (ATC code C*) | 60 856 (86.1) |
AD, Alzheimer's disease; ATC, Anatomical Chemical Therapeutic classification system; CVD, cardiovascular disease; ICD 10, International Classification of Disease; 10th Edition; MEDLAZ, Medicine use and Alzheimer's disease.