Diagnosed PCOS | Probable PCOS | Overall | |||||||
---|---|---|---|---|---|---|---|---|---|
Rate per 1000 PYAR (95% CI) | Adjusted* IRR (95% CI) | p Value | Rate per 1000 PYAR (95% CI) | Adjusted* IRR (95% CI) | p Value | Rate per 1000 PYAR (95% CI) | Adjusted* IRR (95% CI) | p Value | |
Townsend quintile | <0.001 | <0.001 | <0.001 | ||||||
1 | 0.80 (0.76 to 0.84) | 1 | 0.80 (0.76 to 0.84) | 1 | 1.59 (1.53 to 1.65) | 1 | |||
2 | 0.90 (0.85 to 0.95) | 1.14 (1.06 to 1.23) | 0.79 (0.75 to 0.84) | 0.99 (0.92 to 1.07) | 1.69 (1.62 to 1.75) | 1.08 (1.02 to 1.14) | |||
3 | 0.94 (0.90 to 0.99) | 1.12 (1.04 to 1.21) | 0.91 (0.86 to 0.96) | 1.07 (0.99 to 1.15) | 1.85 (1.78 to 1.92) | 1.10 (1.05 to 1.16) | |||
4 | 1.02 (0.97 to 1.07) | 1.15 (1.06 to 1.24) | 0.97 (0.92 to 1.02) | 1.06 (0.98 to 1.15) | 1.98 (1.91 to 2.05) | 1.11 (1.05 to 1.17) | |||
5 | 1.07 (1.01 to 1.13) | 1.15 (1.05 to 1.25) | 1.17 (1.11 to 1.23) | 1.21 (1.11 to 1.32) | 2.23 (2.15 to 2.32) | 1.19 (1.11 to 1.26) | |||
Age (years) | <0.001 | <0.001 | <0.001 | ||||||
15–19 | 1.20 (1.14 to 1.27) | 0.69 (0.64 to 0.74) | 0.54 (0.50 to 0.59) | 0.29 (0.27 to 0.32) | 1.75 (1.67 to 1.83) | 0.49 (0.46 to 0.51) | |||
20–24 | 1.72 (1.64 to 1.80) | 1 | 1.87 (1.79 to 1.96) | 1 | 3.59 (3.47 to 3.70) | 1 | |||
25–29 | 1.51 (1.44 to 1.58) | 0.86 (0.80 to 0.91) | 1.49 (1.42 to 1.56) | 0.78 (0.73 to 0.83) | 2.98 (2.88 to 3.08) | 0.81 (0.78 to 0.85) | |||
30–34 | 1.03 (0.98 to 1.09) | 0.58 (0.54 to 0.62) | 0.86 (0.81 to 0.91) | 0.46 (0.42 to 0.49) | 1.88 (1.81 to 1.96) | 0.51 (0.49 to 0.54) | |||
35–39 | 0.45 (0.42 to 0.49) | 0.26 (0.24 to 0.28) | 0.55 (0.51 to 0.59) | 0.30 (0.27 to 0.32) | 0.99 (0.94 to 1.05) | 0.27 (0.26 to 0.29) | |||
40–44 | 0.17 (0.15 to 0.19) | 0.10 (0.08 to 0.11) | 0.45 (0.42 to 0.48) | 0.24 (0.22 to 0.26) | 0.62 (0.58 to 0.66) | 0.17 (0.16 to 0.18) | |||
Year | <0.001 | <0.001 | <0.001 | ||||||
2004–2007 | 0.91 (0.87 to 0.94) | 1 | 0.82 (0.79 to 0.86) | 1 | 1.73 (1.68 to 1.78) | 1 | |||
2008–2011 | 0.94 (0.91 to 0.98) | 1.00 (0.95 to 1.06) | 0.95 (0.92 to 0.99) | 1.13 (1.07 to 1.19) | 1.89 (1.84 to 1.94) | 1.06 (1.02 to 1.10) | |||
2012–2014 | 0.96 (0.92 to 1.01) | 0.98 (0.92 to 1.04) | 0.98 (0.93 to 1.02) | 1.13 (1.07 to 1.20) | 1.92 (1.86 to 1.98) | 1.04 (1.00 to 1.09) |
*IRR from multilevel Poisson distribution accounted for practice-level variability and adjusted for other variables considered.
IRR, incidence rate ratio; PCOS, polycystic ovary syndrome; PYAR, person-years at risk.