*Bone mineral density is measured by using dual-energy X-ray absorptiometry at baseline and every 48 weeks if a participant wishes.
†Additional laboratory check includes serum levels of RANKL, osteoprotegerin, osteocalcin and leptin.
25(OH)D, 25-hydroxy vitamin D; OGTT, oral glucose tolerance test; RANKL, receptor activator of the nuclear factor κ-B ligand.