Table 1

Summary of key characteristics of studies included in the review

CharacteristicsStudies (n)Study reference (see online supplementary table S2)
Study country
 UK210, 31
 Germany16
 Netherlands37, 11, 55,
 Canada113
 USA471, 2, 3, 4, 5, 8, 9, 12, 14, 17, 18, 19, 20, 22, 23, 24, 25, 26, 27, 28, 29, 30, 33, 34, 35, 36, 37, 38, 39, 40, 44, 45, 46, 48, 49, 50, 52, 53, 54, 56, 57, 58, 59, 60, 62, 63, 64
 Taiwan415, 32, 43, 51
 Japan416, 21, 42, 47
 South Korea241, 61
Aspect of centralisation
 Hospital volume511, 2, 3, 4, 6, 8, 9, 12, 15, 16, 17, 18, 19, 20, 21, 22, 24, 25, 26 ,27, 28, 29, 30, 32, 33, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 57, 58, 59, 60, 62, 63, 64
 Hospital location211, 31
 Healthcare specialisation105, 7, 10, 13, 14, 23, 34, 54, 55, 61
 Multidisciplinary care156
Study design
 Decision analytic modelling114, 5, 6, 8, 10, 11, 12, 27, 54, 55, 60
 Cohort341, 2, 3, 7, 8, 13, 14, 15, 17, 18, 19, 23, 24, 25, 26, 29, 32, 35, 36, 39, 42, 43, 44, 47, 51, 52, 53, 56, 57, 58, 59, 62, 63, 64,
 Case control233, 45
 Cross-sectional159, 16, 20, 21, 22, 28, 30, 37, 38, 40, 41, 46, 48, 49, 50,
 Before and after310, 31, 61
 Case series134
Economic evaluation type
 Cost utility analysis (CUA)104, 5, 6, 10, 11, 13, 14, 27, 54, 55
 Cost-effectiveness analysis (CEA)47, 8, 12, 56
 Cost-consequence analysis (CCA)501, 2, 3, 9, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 57, 58, 59, 60, 61, 62, 63, 64
Economic perspective
 Societal47, 8, 12, 54
 Societal and health insurance16
 Healthcare410, 13, 58, 63
 Third-party payer327, 56, 60
 Not stated521, 2, 3, 4, 5, 9, 11, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 55, 57, 59, 61, 62, 64
Targeted health services
 Emergency144, 5, 6, 10, 13, 14, 17, 30, 31, 32, 33, 34, 46, 61
 Non-emergency501, 2, 3, 7, 8, 9, 11, 12, 15, 16, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 62, 63, 64