Model | HERDOO2 | Vienna | DASH | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Measurement statistics used | Mean (SD) or frequency (%) | Median (25th, 75th centiles) or frequency (%) | Median or per cent | |||||||
Patient characteristic | n | Recurrence | n | No recurrence | n | All | n | Recurrence | n | No recurrence |
Age (years) | 91 | 53.6 (14.8) | 555 | 52.3 (17.9) | 929 | 54 (43, 63) | 239 | 63 | 1579 | 61 |
Male proportion | 91 | 63 (69.2) | 555 | 269 (48.5) | 929 | 562 (60) | 239 | 69.40% | 1579 | 48.60% |
Site (distal DVT) proportion | 91 | NA | 555 | NA | 929 | 164 (17.7) | 239 | NA | 1579 | NA |
Site (proximal DVT) proportion | 91 | NA | 555 | NA | 929 | 327 (35.2) | 239 | NA | 1579 | NA |
Site (PE) proportion | 91 | NA | 555 | NA | 929 | 438 (47.1) | 239 | NA | 1579 | NA |
BMI (kg/m2) | 91 | 30.3 (7.6) | 555 | 28.9 (7.1) | 909 | 27.1 (24.4, 30.1) | * | 27.2 | * | 27.2 |
D-dimer (µg/L)† | 91 | 383 (738) | 555 | 294 (314) | 832 | 355 (236, 558) | 239 | 67.7%‡ | 1579 | 42%‡ |
Factor V Leiden proportion | 91 | 19 (20.9) | 554 | 81 (14.6) | 916 | 224 (24.4) | 239 | NA | 1579 | NA |
Duration of OAC (months) | 91 | 5 to 7 | 555 | 5 to 7 | 929 | 6.6 (6.1, 8.0) | 239 | 6.7 | 1579 | 6.8 |
Duration of follow-up (months) | 18 (1, 47)§ | 43.3 (14.7, 78.5) | 22.4 |
*BMI data available for 802 participants, no reporting of number of participants by event status.
†D-dimer measured in ng/mL within the DASH article.
‡DASH reported the percentage with abnormal D-dimer, defined as ≥500 ng/mL .
§Follow-up for HERDOO2 presented as mean (range).
NA—the information was not provided for these fields. In particular, both the HERDOO2 and DASH studies did not include patients with distal DVT index events a priori. And the DASH study did not provide figures for the proportion of patients with factor V Leiden, but the percentages of patients with thrombophilia were 23.4% and 20.9% for recurrence and non-recurrence, respectively.
BMI, body mass index; DVT, deep vein thrombosis; OAC, oral anticoagulants; PE, pulmonary embolism.