Drug dosing schedule
| Renal function | Colistin maintenance dose* | Meropenem dosing |
|---|---|---|
| CrCl ≥50 mL/min† | 4.5 MIU q12 h | 2 g q8 h |
| CrCl <50 mL/min, without renal replacement therapy | Total daily dose in MIU=(2×(1.5×CrCl+30))/30 | CrCl 26–50 mL/min: 2 g q12 hCrCl 10–25 mL/min: 1 g q12 h |
| Continuous renal replacement therapy | Fixed dose of 6 MIU q12 h | 1 g q12 h |
| Intermittent haemodialysis | 1 MIU q12 h, with a 1 MIU supplemental dose after dialysis | 1 g q24 h with a supplemental dose given after dialysis |
*All patients receive a loading dose of 9 MIU regardless of renal function. Adjustment refers only to the maintenance dose started 12 h after the loading dose.
†CrCl should be expressed in mL/min/1.73 m2, using the modification of diet in renal disease (MDRD) formula, Cockcroft and Gault equation or other means.