Selection | Inclusion | M3 | M6 | M9 | M12 | |
---|---|---|---|---|---|---|
Inclusion criteria | × | |||||
Informed consent | × | |||||
Somatic parameters weight, height, BMI, waist circumference, blood pressure, temperature | – | × | × | × | × | × |
Tanner stage | – | × | – | × | – | × |
AIMS36 | ||||||
SAS37 38 | – | × | × | × | × | × |
BARS39 | ||||||
BFCRS40 | ||||||
Laboratory assessment | ||||||
Full blood count, liver enzymes, creatine phosphokinase, glycaemia, cholesterol (total, HDL, LDL), triglycerides, hsCRP, | – | × | × | × | × | × |
Prolactin, insulin, HbA1c, HOMA | – | × | × | × | – | × |
Vitamin D | – | × | × | – | – | × |
Thyroid hormones | – | × | – | – | – | × |
ECG, QTc interval | – | × | – | × | – | × |
Semistructured interview K-SADS41 MINI/MINI-kid42 | – | × | – | – | – | × |
Clinician questionnaires CGI-S43 44 | – | × | × | × | × | × |
CGAS45 46 | – | × | – | × | – | × |
PAERS47 | – | × | × | × | × | × |
Patient Questionnaires | ||||||
QEWP48 | – | × | × | × | × | × |
HAQ49 50 | – | – | × | × | × | × |
SDS51 | – | × | × | × | × | × |
Dennison52 | – | × | × | × | × | × |
AIMS, abnormal involuntary movement scale; BARS, barnes akathisia rating scale; BFCRS, bush francis catatonia rating scale; BMI, body mass index; CGAS: clinical global assessment scale; CGI-S, clinical global impression scale; ECG, electrocardiogram; HAQ, helping alliance questionnaire; HDL, high-density lipoprotein; hs-CRP, high sensitivity C-reactive protein; HbA1c, glycated haemoglobin; HOMA, insulin resistance; K-SADS, SAS, simpson and angus scale; LDL, low-density lipoprotein; MINI, mini international neuropsychiatric interview; PAERS, pediatric adverse event rating scale; QEWP, questionnaire of eating and weight patterns; schedule for affective disorders and schizophrenia for school age children; SDS, sheehan disability scale.