Table 4

Association between termination of pregnancy (TOPFA) and maternal characteristics in fetuses with prenatal diagnosis in the EPICARD study

	TOPFA
	All CHD								Isolated CHD*
	N	Per cent	OR	95% CI	p Value†	Adjusted OR‡	95% CI	p Value†	N	Per cent	OR	95% CI	p Value†	Adjusted OR‡	95% CI	p Value†
	835	41.4		38.1 to 44.9					468	27.6		23.6 to 31.9
Age (year)
<25	93	40.9	0.9	0.6 to 1.4	0.05	0.8	0.4 to 1.4	0.38	53	32.1	1.1	0.6 to 2.0	0.08	1.0	0.4 to 2.5	0.65
25–34	477	43.8	Ref			Ref			298	30.2	Ref			Ref
35–37	114	45.6	1.1	0.7 to 1.6		1.2	0.7 to 1.9		60	23.3	0.7	0.4 to 1.3		1.0	0.4 to 2.6
>37	149	31.5	0.6	0.4 to 0.9		0.7	0.5 to 1.2		56	14.3	0.4	0.2 to 0.8		0.5	0.2 to 1.5
Occupation
Professional	165	43.0	Ref	Ref	0.08	Ref	Ref	0.42	97	24.7	Ref	Ref	0.61	Ref	Ref	0.25
Intermediate	139	33.8	0.7	0.4 to 1.1		0.8	0.5 to 1.4		89	19.1	0.7	0.4 to 1.4		1.2	0.5 to 3.0
Administrative/ Public service	73	41.1	0.9	0.5 to 1.6		1.1	0.6 to 2.1		39	28.2	1.2	0.5 to 2.8		2.2	0.7 to 6.9
Other	131	38.9	0.8	0.5 to 1.3		1.2	0.7 to 2.1		72	27.8	1.2	0.6 to 2.3		2.5	0.9 to 6.6
None	231	30.3	0.6	0.4 to 0.9		0.8	0.4 to 1.3		129	20.9	0.8	0.4 to 1.5		1.1	0.4 to 2.9
Geographic origin
France	380	46.1	Ref	Ref	<0.0001	Ref	Ref	0.0004	225	29.8	Ref	Ref	0.08	Ref	Ref	0.01
North African	148	26.4	0.4	0.3 to 0.6		0.4	0.2 to 0.6		79	16.5	0.5	0.2 to 0.9		0.2	0.1 to 0.5
Other African	132	34.9	0.6	0.4 to 0.9		0.6	0.3 to 1.0		64	25.0	0.8	0.4 to 1.5		0.4	0.1 to 1.0
Other origins	172	48.8	1.1	0.8 to 1.6		1.1	0.7 to 1.8		100	33.0	1.2	0.7 to 1.9		0.7	0.3 to 1.5
Department of residence
Paris	280	42.1	Ref	Ref	0.25	Ref	Ref	0.88	148	25.7	Ref	Ref	0.14	Ref	Ref	0.23
Hauts-de-Seine	207	38.7	0.9	0.6 to 1.2		0.9	0.6 to 1.4		122	27.1	1.1	0.6 to 1.8		1.2	0.6 to 2.5
Seine-Saint-Denis	214	38.8	0.9	0.6 to 1.3		0.9	0.6 to 1.5		109	22.9	0.9	0.5 to 1.5		0.5	0.2 to 1.2
Val-de-Marne	134	48.5	1.3	0.9 to 2.0		1.1	0.7 to 1.8		89	37.1	1.7	1.0 to 3.0		1.2	0.6 to 2.7

*Isolated CHD: excluding chromosomal or other anomalies.
†p Value of the Wald test.
‡Adjusted OR for age, geographic origin, occupation, department of residence and categories of CHD (ACC-CHD33).
ACC, anatomic and clinical classification; CHD, congenital heart defects; EPICARD, EPIdémiologie des CARDiopathies congénitales; TOPFA, termination of pregnancy for fetal anomaly.