Summary of risk estimates (HRs) for different measures of depression (continuous measures of symptomatology or categorical clinical thresholds), and different dementia outcome categories (all-cause dementia, Alzheimer's disease, vascular dementia)
| Depression assessment | Dem | AD | ||||||
|---|---|---|---|---|---|---|---|---|
| HRs (n) | HR | 95% CI | I2, % | HRs (n) | HR | 95% CI | I2, % | |
| Clinical thresholds | ||||||||
| All | 11 | 1.98 | 1.50 to 2.63 | 38.34 | 10 | 2.04 | 1.40 to 2.98 | 60.28 |
| CES-D>20 | 5 | 1.83 | 0.95 to 3.52 | 71.85 | 5 | 1.97 | 0.96 to 4.04 | 70.96 |
| CES-D>16 | 9 | 1.69 | 1.46 to 1.97 | 0.00 | 6 | 1.58 | 1.25 to 2.00 | 0.00 |
| Continuous measures | ||||||||
| All | 10 | 1.05 | 1.02 to 1.08 | 63.06 | 10 | 1.06 | 1.02 to 1.10 | 62.06 |
| CES-D/HAM | 8 | 1.05 | 1.02 to 1.07 | 54.82 | 6 | 1.06 | 1.00 to 1.12 | 72.87 |
CES-D, Centre for Epidemiological Studies Depression scale; HAM, Hamilton rating scale for depression.