Coleman23 | 2012 | RCT with repeated measures
15-week intervention period Intervention consisted of stretching, strength and resistance, and aerobic exercise (frequency of exercise sessions and duration is not reported)
| To compare usual care with a home-based individualised exercise programme (HBIEP) in patients receiving intensive treatment for MM and epoetin alfa therapy |
No statistically significant differences existed among the experimental and control groups for fatigue, sleep or performance (aerobic capacity) (p>0.05) Exercise combined with epoetin alfa helped alleviate anaemia
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Coleman22 | 2008 | RCT
15-week intervention period Intervention consisted of stretching, strength and resistance, and aerobic exercise (frequency of exercise session and duration is not reported)
| To determine the effect of epoetin therapy (short term vs long term) with and without a home-based individualised exercise programme that incorporated aerobic and strength resistance training for patients being treated with high-dose chemotherapy and autologous peripheral-blood stem cell transplantation for MM |
Recovery and treatment response were not significantly different between groups after transplantation The exercise group had significantly fewer red blood cell transfusions and fewer attempts at stem cell collection (p<0.025) Serious adverse events were similar in each group (p>0.05)
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Coleman24 | 2003 | RCT
Intervention period, session frequency and duration is not reported Intervention consisted of stretching, strength and resistance, and aerobic exercise
| To test the feasibility of home-based exercise therapy for patients receiving high-dose chemotherapy and autologous peripheral blood stem cell transplantation as treatment for MM |
Individuals assigned to exercise gained an average lean body weight of 0.40 kg per month The non-exercise group experienced and average decline in lean body weight of −0.44 kg/month (p<0.01) The study suggests that an exercise programme for patients receiving aggressive treatment for MM is feasible and may be effective in decreasing fatigue and mood disturbance while improving sleep
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Groeneveldt25 | 2013 | Single arm pilot study
6-month intervention period Intervention consisted of taking part in stretching, strength and resistance, and aerobic exercise three times a week
| To assess the feasibility (accrual rate, acceptability and adherence) and safety of an exercise programme for MM survivors |
The exercise programme was feasible and safe for patients with MM and there was high attendance and acceptability Benefits were evident in patients reported outcomes of QOL, fatigue and measured muscle strength (all p<0.01)
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