Factors associated with time to reach severe dementia
| Unadjusted HRs | p Value | Adjusted HRs | p Value | |
|---|---|---|---|---|
| Age at baseline, years | 1.00 (0.97 to 1.04) | 0.781 | ||
| Diagnoses, DLB vs AD | 2.35 (1.39 to 3.99) | 0.002 | 2.04 (1.12 to 3.72) | 0.020 |
| Sex, females vs males | 0.6 (0.35 to 1.02) | 0.057 | 0.83 (0.45 to 1.53) | 0.556 |
| Education in years | 1.01 (0.92 to 1.10) | 0.907 | ||
| Duration of symptoms in years | 1.13 (1.00 to 1.27) | 0.048 | 1.15 (1.01 to 1.29) | 0.030 |
| MMSE total scores | 0.79 (0.71 to 0.89) | <0.0005 | 0.82 (0.73 to 0.93) | 0.002 |
| CIRS total scores | 1.02 (0.90 to 1.16) | 0.745 | ||
| CDR global scores | 3.26 (1.80 to 5.89) | <0.0005 | 2.42 (1.26 to 4.65) | 0.008 |
Cox regression, time until CDR=3. HRs presented with 95% CI.
AD, Alzheimer's dementia; CDR, Clinical Dementia Rating; CIRS, Cumulative Illness Rating Scale; DLB, Dementia with Lewy bodies; MMSE, Mini-Mental State Examination.