Study ID | Location | Study year(s) | Incident cases | Patient-years | Incidence per 1 000 000 person-years (95% CIs) | Age of onset | Comments |
---|---|---|---|---|---|---|---|
Eastern Asia | |||||||
Chen 196820 | Guam | 1960–1966 | 0 | 265 825 | 0.00 (0 to 13.9) | Not stated | |
Chang 199423 | Hong Kong, China | 1984–1991 | 20 | 43 520 000 | 0.46 (0.28 to 0.71)* | 37.6 (range 20–52) | |
Chen 201024 | Taiwan | 2000–2007 | 165 | 15 900 000 | 1.04 (0.89 to 1.21) | Not stated | Average incidence between 2000 and 2007 |
Australasia | |||||||
McCusker 200031 | NSW, Australia | 1991 and 1996 | 1991=26 1996=39 | 1991=5 732 031 1996=6 038 969 | 1991=4.5 (3.0 to 6.7) 1996=6.5 (4.6 to 8.8) | 47.9 (SD 13.7) | |
Europe | |||||||
Palo 198725 | Finland | 1980s | 2† | 4 900 000 | 0.2 to 0.4 (0.02 to 1.3)* | Not stated | |
Govoni 198827 | Ferrara, Italy | 1971–1987 | 14 | 6 032 096‡ | 1.1 (0.4 to 2.3) | Not stated | |
Ramos-Arroyo 200530 | Navara and Basque, Spain | 1994–2002 | 111 | 21 165 000 | 4.7 (4.5 to 6.3)* | 43.7 (SD 15) | |
Mercy 200821 | Cambridge UK | 2000–2006 | 9 | 453 600 | 8.0 (2.0 to 23) | Not stated | Restricted age range (45–64 years) |
Panas 201129 | Greece | 1995–2008 | 48† | 10 964 020 | 4.38 (3.23 to 5.50) | 44.0 (SD 12.9) | |
Sackley 201128 | UK | 2004–2008 | 85 | 14 713 708 | 5.71 (4.45 to 7.07) | 48.3 (SD14.) | Average incidence between 2004 and 2008 |
Sveinsson 201226 | Iceland | 1988–2007 | 8 | 5 714 285‡ | 1.4 (0.6 to 2.8)* | 51 (range 28–68) | |
Douglas 201322 | UK | 1990–2010 | 12 | 17 142 857 | 0.70 (0.36 to 1.22) | Median=15 (range 5–20) | Restricted to juvenile HD |
Current study | UK | 1990–2010 | 393 | 54 907 468 | 7.2 (6.5 to 7.9) | 52 years (SD 16) | Also includes annual incidence rates1990–2010 |
North America | |||||||
Kokman 199432 | Minnesota, USA | 1950–1989 | 10 | 4 134 000‡ | Definite=3.0 (1.0 to 5.0) Definite+probability=5.0 (3.0 to 9.0) | Not stated | . |
Almqvist 200133 | British Columbia, Canada | 1996–1999 | 110 | 16 058 394‡ | 6.9 (5.7 to 8.3)* | 46.9 (SD 13.7) | Author states population is ‘approximate’ |
*95% CIs not included in the published report but estimated for this review.
†Numbers of patients with HD calculated by back extrapolation.
‡Patient-years calculated by back extrapolation.
HD, Huntington's disease; NSW, New South Wales.