Relationship between DELCs and the classical risk factors
| Classical risk | DELC | CHD | Controls | OR (95% CI) | p Value |
|---|---|---|---|---|---|
| Age | |||||
| 0 | 0 | 59 | 33 | 1 | 0.000 |
| 0 | 1 | 83 | 11 | 4.220 (1.974 to 9.021) | 0.000 |
| 1 | 0 | 41 | 36 | 0.637 (0.343 to 1.182) | 0.153 |
| 1 | 1 | 262 | 33 | 4.441 (2.539 to 7.767) | 0.000 |
| SI=1.21 | SIM=1.65 | RERI=0.58 | AP=0.132 | ||
| Sex | |||||
| 0 | 0 | 26 | 38 | 1 | 0.000 |
| 0 | 1 | 73 | 19 | 5.615 (2.762 to 11.418) | 0.000 |
| 1 | 0 | 74 | 31 | 3.489 (1.818 to 6.694) | 0.000 |
| 1 | 1 | 272 | 25 | 15.902 (8.339 to 30.322) | 0.000 |
| SI=2.09 | SIM=0.81 | RERI=7.79 | AP=0.49 | ||
| Smoking status | |||||
| 0 | 0 | 62 | 55 | 1 | 0.000 |
| 0 | 1 | 217 | 33 | 5.833 (3.483 to 9.769) | 0.000 |
| 1 | 0 | 38 | 14 | 2.408 (1.181 to 4.908) | 0.016 |
| 1 | 1 | 128 | 11 | 10.323 (5.050 to 21.099) | 0.000 |
| SI=1.49 | SIM=0.73 | RERI=3.08 | AP=0.29 | ||
AP, proportion of disease attributable to interaction; RERI, relative excess risk due to interaction; SI, SI, synergy index for interaction in a multiplicative model; SI, synergy index for interaction in an additive model; DELC, diagonal earlobe crease.