Demographic characteristics of Gen3G participants and of the general population of pregnant women who delivered at the CHUS over same time period
| Gen3G participants (n=1024*) | CHUS patients, between 2008 and 2011 (n=7710) | |||
|---|---|---|---|---|
| Characteristics | N | Median [IQR] or N (%) | N | Median [IQR] or N (%) |
| Age (years) | 1024 | 28.0 [25.0–31.0] | 7507 | 28.0 [24.0–31.0] |
| European descent | 1012 | 964 (95.3) | 5224 | 4758 (91.1) |
| Primiparity | 1024 | 354 (34.6) | 8579† | 2849 (33.2) |
| Self-reported pre-pregnancy BMI (kg/m2) | 1014 | 23.2 [20.9–27.3] | 7225 | 23.2 [20.9–26.7] |
| Abnormal glucose tolerance at first trimester‡ | 1024 | 9 (0.9) | 3047 | 56 (1.8) |
| GDM diagnosis at V2 | 5354 | 530 (9.9)§ | ||
| According to CDA¶ | 823 | 43 (5.2) | ||
| According to IADPSG | 823 | 80 (8.9) | ||
| Gestational week at which GDM screening was performed in the second trimester | 893 | 26.2 [25.6–27.1] | 5361 | 26.4 [26.0–28.0] |
2008 CDA criteria: 50 g glucose challenge followed by a 1 h plasma glucose. If 1 h plasma glucose <7.8, no GDM. If 1 h plasma glucose ≥10.3, GDM diagnosis. If 1 h plasma glucose is 7.8–10.2, reassess with a 75 g OGTT (fasting plasma glucose <5.3, 1 h plasma glucose <10.6, 2 h plasma glucose <8.9; if one value is exceeded, IGT diagnosis; if more than one value is exceeded, GDM diagnosis).
IADPSG criteria: 75 g OGTT with fasting, 1 and 2 h plasma glucose. If fasting plasma glucose ≥5.1 and/or 1 h plasma glucose ≥10.0 and/or 2 h plasma glucose ≥8.5, GDM is diagnosed.
*In total,1034 participants accepted inclusion in the study, but multiple pregnancies (n=10) were excluded from these analyses.
†Total number of pregnancies, completed or not, seen at least once at the CHUS between 2008 and 2011.
‡Abnormal glucose tolerance was defined as reaching a blood glucose level ≥10.3 mmol/L 1 h after the 50 g GCT.
§Determined by the per cent of women referred to our institution's Endocrinology in Pregnancy Clinic; not all women performed 75 g OGTT or performed it at our institution.
¶Including GDM and IGT diagnoses as per the 2008 CDA guidelines for glucose levels above threshold at one time point (IGT diagnosis) or two time points (GDM diagnosis) during the 75 g OGTT (three points: fasting, 1 and 2 h).
BMI, body mass index; CDA, Canadian Diabetes Association; CHUS, Centre Hospitalier Universitaire de Sherbrooke; GDM, gestational diabetes mellitus; Gen3G, Genetics of Glucose regulation in Gestation and Growth; IADPSG, International Association of the Diabetes and Pregnancy Study Groups; IGT, impaired glucose tolerance; OGTT, oral glucose tolerance test.